https://scholars.lib.ntu.edu.tw/handle/123456789/515006
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Chen C.-Y. | en_US |
dc.contributor.author | VIN-CENT WU | en_US |
dc.contributor.author | Lin C.-J. | en_US |
dc.contributor.author | Lin C.-S. | en_US |
dc.contributor.author | Pan C.-F. | en_US |
dc.contributor.author | Chen H.-H. | en_US |
dc.contributor.author | YU-FENG LIN | en_US |
dc.contributor.author | TAO-MIN HUANG | en_US |
dc.contributor.author | Chen L.-K. | en_US |
dc.contributor.author | Wu C.-J. | en_US |
dc.contributor.author | TAI-SHUAN LAI | en_US |
dc.contributor.author | I-JUNG TSAI | en_US |
dc.contributor.author | CHUN-FU LAI | en_US |
dc.contributor.author | TZONG-SHINN CHU | en_US |
dc.contributor.author | YUNG-MING CHEN | en_US |
dc.contributor.author | Wang W.-J. | en_US |
dc.contributor.author | Chang Y.-H. | en_US |
dc.contributor.author | Chen C.-Y. | en_US |
dc.contributor.author | Shiao C.-C. | en_US |
dc.contributor.author | Wang W.-J. | en_US |
dc.contributor.author | Lin Y.-H. | en_US |
dc.contributor.author | Wu C.-H. | en_US |
dc.contributor.author | YU-CHANG YEH | en_US |
dc.contributor.author | Lai C.-H. | en_US |
dc.contributor.author | Tseng L.-J. | en_US |
dc.contributor.author | KWAN-DUN WU | en_US |
dc.date.accessioned | 2020-09-28T07:04:27Z | - |
dc.date.available | 2020-09-28T07:04:27Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0025-6196 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055027596&doi=10.1016%2fj.mayocp.2018.06.023&partnerID=40&md5=92d47f587c2d612e0a1ec5cf1b2bdae7 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/515006 | - |
dc.description.abstract | Objective: To focus on the potential beneficial effects of the pleiotropic effects of dipeptidyl peptidase-4 inhibitors (DPP4is) on attenuating progression of diabetic kidney disease in reducing the long-term effect of the acute kidney injury (AKI) to chronic kidney disease (CKD) transition. Patients and Methods: Data from the National Health Insurance Research Database from January 1, 1999, to July 31, 2011, were analyzed, and patients with diabetes weaning from dialysis-requiring AKI were identified. Cox proportional hazards models and inverse-weighted estimates of the probability of treatment were used to adjust for treatment selection bias. The outcomes were incident end-stage renal disease (ESRD) and mortality, major adverse cardiovascular events, and hospitalized heart failure. Results: Of a total of 6165 patients with diabetes weaning from dialysis-requiring AKI identified, 5635 (91.4%) patients were DPP4i nonusers and 530 (8.6%) patients were DPP4i users. Compared with DPP4i nonusers, DPP4i users had a lower risk of ESRD (hazard ratio, 0.81; 95% CI, 0.70-0.94; P=.04) and all-cause mortality (hazard ratio, 0.28; 95% CI, 0.23-0.34; P<.001) after adjustments for CKD, advanced CKD, and angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker use. In contrast, the risk of major adverse cardiovascular events and hospitalized heart failure did not differ significantly between groups. Conclusion: Dipeptidyl peptidase-4 inhibitor users had a lower risk of ESRD and mortality than did nonusers among patients with diabetes after weaning from dialysis-requiring AKI. Therefore, a prospective study of AKI to CKD transitions after episodes of AKI is needed to optimally target DPP4i interventions. ? 2018 Mayo Foundation for Medical Education and Research | en_US |
dc.publisher | Elsevier Ltd | en_US |
dc.relation.ispartof | Mayo Clinic Proceedings | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alpha glucosidase inhibitor; angiotensin receptor antagonist; antidiabetic agent; dipeptidyl carboxypeptidase inhibitor; dipeptidyl peptidase IV inhibitor; glitazone derivative; insulin; meglitinide; metformin; sulfonylurea; dipeptidyl peptidase IV inhibitor; acute kidney failure; adult; aged; all cause mortality; Article; cardiovascular risk; cohort analysis; controlled study; dialysis; drug effect; drug potentiation; end stage renal disease; female; heart failure; human; major adverse cardiac event; major clinical study; male; mortality; non insulin dependent diabetes mellitus; outcome assessment; acute kidney failure; case control study; chronic kidney failure; complication; diabetic nephropathy; disease exacerbation; middle aged; non insulin dependent diabetes mellitus; proportional hazards model; prospective study; Acute Kidney Injury; Adult; Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dipeptidyl-Peptidase IV Inhibitors; Disease Progression; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Proportional Hazards Models; Prospective Studies | - |
dc.title | Improvement in Mortality and End-Stage Renal Disease in Patients With Type 2 Diabetes After Acute Kidney Injury Who Are Prescribed Dipeptidyl Peptidase-4 Inhibitors | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.mayocp.2018.06.023 | - |
dc.identifier.pmid | 30343892 | - |
dc.identifier.scopus | 2-s2.0-85055027596 | - |
dc.relation.pages | 1760-1774 | en_US |
dc.relation.journalvolume | 93 | en_US |
dc.relation.journalissue | 12 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Geriatrics and Gerontology-NTUH | - |
crisitem.author.dept | National Taiwan University Hospital Bei-Hu Branch | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-7935-0991 | - |
crisitem.author.orcid | 0000-0002-4350-7755 | - |
crisitem.author.orcid | 0000-0002-9387-0798 | - |
crisitem.author.orcid | 0000-0002-0552-372X | - |
crisitem.author.orcid | 0000-0003-3967-9412 | - |
crisitem.author.orcid | 0000-0003-2109-1522 | - |
crisitem.author.orcid | 0000-0002-5291-2509 | - |
crisitem.author.orcid | 0000-0002-9241-1258 | - |
crisitem.author.orcid | 0000-0001-5143-5520 | - |
crisitem.author.orcid | 0000-0002-3339-1509 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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