https://scholars.lib.ntu.edu.tw/handle/123456789/515054
DC Field | Value | Language |
---|---|---|
dc.contributor.author | CHE-WEI LIAO | en_US |
dc.contributor.author | LIAN-YU LIN | en_US |
dc.contributor.author | CHI-SHENG HUNG | en_US |
dc.contributor.author | Lin Y.-T. | en_US |
dc.contributor.author | Chang Y.-Y. | en_US |
dc.contributor.author | SHUO-MENG WANG | en_US |
dc.contributor.author | VIN-CENT WU | en_US |
dc.contributor.author | KWAN-DUN WU | en_US |
dc.contributor.author | YI-LWUN HO | en_US |
dc.contributor.author | Satoh F. | en_US |
dc.contributor.author | YEN-HUNG LIN | en_US |
dc.date.accessioned | 2020-09-28T07:04:38Z | - |
dc.date.available | 2020-09-28T07:04:38Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84958576288&doi=10.1038%2fsrep20862&partnerID=40&md5=f63b4f1864b86ba14f0b6bb46e2512a9 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/515054 | - |
dc.description.abstract | Primary aldosteronism not only results in hypertension but also stiffer arteries. The time course and factors predicting the reversal of arterial stiffness after treatment are unclear. We prospectively enrolled 102 patients with aldosterone-producing adenoma (APA) from March 2006 to January 2012. We measured the pulse wave velocity (PWV) between brachial-ankle (baPWV) and heart-ankle (haPWV) before, 6 and 12 months after their adrenalectomy. After treatment, the PWV decreased significantly during the first 6 months (both p < 0.001), but no further reduction in the following 6 months. The determinant factors for baseline baPWV were age, duration of hypertension, and baseline systolic blood pressure (SBP) in multivariate linear regression analysis, similar with baseline haPWV (determinants: age, duration of hypertension, baseline SBP and diastolic blood pressure (DBP)). In multivariate linear regression analysis, the decrease in DBP at 6 months (δ "DBP 0-6mo) and baseline baPWV were significantly associated with the decrease in baPWV at 6 months (δ "baPWV 0-6mo). The associated factors of the change in haPWV at 6 months (δ "haPWV 0-6mo) were baseline haPWV, δ "DBP 0-6mo and change in log-transformed plasma renin activity. Our result suggested that reversal of arterial stiffness in APA patients occurred early after adrenalectomy and determined by baseline vascular condition, hemodynamic factors, and humoral factors. | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.ispartof | Scientific Reports | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | aldosterone; adenoma; adrenalectomy; adult; ankle brachial index; arterial stiffness; biosynthesis; complication; female; hemodynamics; human; hyperaldosteronism; male; metabolism; middle aged; pathology; pathophysiology; prospective study; pulse wave; treatment outcome; Vascular Diseases; Adenoma; Adrenalectomy; Adult; Aldosterone; Ankle Brachial Index; Female; Hemodynamics; Humans; Hyperaldosteronism; Male; Middle Aged; Prospective Studies; Pulse Wave Analysis; Treatment Outcome; Vascular Diseases; Vascular Stiffness | - |
dc.title | Time course and factors predicting arterial stiffness reversal in patients with aldosterone-producing adenoma after adrenalectomy: Prospective study of 102 patients | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/srep20862 | - |
dc.identifier.pmid | 26883298 | - |
dc.identifier.scopus | 2-s2.0-84958576288 | - |
dc.relation.pages | 20862 | en_US |
dc.relation.journalvolume | 6 | en_US |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Master's Program in Smart Medicine and Health Informatics (SMARTMHI) | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUHHC | - |
crisitem.author.dept | Urology-NTUHBH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0001-7156-5381 | - |
crisitem.author.orcid | 0000-0001-7505-6429 | - |
crisitem.author.orcid | 0000-0003-2090-1757 | - |
crisitem.author.orcid | 0000-0001-7935-0991 | - |
crisitem.author.orcid | 0000-0002-3339-1509 | - |
crisitem.author.orcid | 0000-0002-8936-9570 | - |
crisitem.author.orcid | 0000-0001-8153-1441 | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | International College | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Bei-Hu Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學系 |
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