https://scholars.lib.ntu.edu.tw/handle/123456789/515629
Title: | Recombinant activated factor VII as a promising adjuvant therapy for postpartum hemorrhage in the practice of obstetric anesthesia: Experience from a university hospital in Taiwan | Authors: | Jan J.-Y. SHIN-YU LIN Lin C.-H. CHIEN-NAN LEE SHOU-ZEN FAN YIN-YI HAN |
Issue Date: | 2011 | Journal Volume: | 37 | Journal Issue: | 7 | Start page/Pages: | 901-907 | Source: | Journal of Obstetrics and Gynaecology Research | Abstract: | Massive postpartum hemorrhage is one of the major complications in the peripartum period. In some critical cases, hemostasis is hard to achieve even after a hysterectomy has been performed. Recombinant activated factor VII has been reported as a promising adjuvant therapy for obstetric hemorrhage, although it remains unlicensed for this indication. Eight cases receiving recombinant activated factor VII in postpartum hemorrhage refractory to the conventional therapy in a Taiwanese hospital were analyzed retrospectively. A good response, defined as bleeding control in 15 min, was achieved in six patients (75%) with a single dose ranging from 55 to 105 μg/kg. The two patients with a poor response were later discovered to have had unsolved birth canal injuries. No drug-related adverse effects were noted. We recommend that any surgical bleeding should first be controlled, as well as the correction of metabolic and hematological abnormalities; however, in the situation of intractable postpartum hemorrhage, recombinant activated factor VII offers a salvage therapy and should be considered early, even before hysterectomy. ? 2011 The Authors. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/515629 | ISSN: | 1341-8076 | DOI: | 10.1111/j.1447-0756.2010.01422.x | SDG/Keyword: | fresh frozen plasma; methylergometrine; oxytocin; recombinant blood clotting factor 7a; absence of side effects; article; bleeding; chorioamnionitis; clinical article; disease control; disseminated intravascular clotting; drug indication; erythrocyte transfusion; female; human; hysterectomy; maternal morbidity; maternal mortality; medical practice; medical record review; obstetric anesthesia; placenta accreta; postoperative period; postpartum hemorrhage; repeated drug dose; retrospective study; salvage therapy; single drug dose; Taiwan; thrombocyte transfusion; treatment response; university hospital; uterine atony; vaginal delivery; Adult; Anesthesia, Obstetrical; Drug Resistance; Factor VIIa; Hemostatics; Hospitals, University; Humans; Male; Off-Label Use; Postpartum Hemorrhage; Recombinant Proteins; Retrospective Studies; Salvage Therapy; Taiwan; Time Factors; Young Adult |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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