https://scholars.lib.ntu.edu.tw/handle/123456789/515629
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Jan J.-Y. | en_US |
dc.contributor.author | SHIN-YU LIN | en_US |
dc.contributor.author | Lin C.-H. | en_US |
dc.contributor.author | CHIEN-NAN LEE | en_US |
dc.contributor.author | SHOU-ZEN FAN | en_US |
dc.contributor.author | YIN-YI HAN | en_US |
dc.creator | Jan J.-Y. ;Lin S.-Y. ;Lin C.-H. ;Lee C.-N. ;Fan S.-Z. ;Yin-Yi Han | - |
dc.date.accessioned | 2020-09-29T05:32:24Z | - |
dc.date.available | 2020-09-29T05:32:24Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1341-8076 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/515629 | - |
dc.description.abstract | Massive postpartum hemorrhage is one of the major complications in the peripartum period. In some critical cases, hemostasis is hard to achieve even after a hysterectomy has been performed. Recombinant activated factor VII has been reported as a promising adjuvant therapy for obstetric hemorrhage, although it remains unlicensed for this indication. Eight cases receiving recombinant activated factor VII in postpartum hemorrhage refractory to the conventional therapy in a Taiwanese hospital were analyzed retrospectively. A good response, defined as bleeding control in 15 min, was achieved in six patients (75%) with a single dose ranging from 55 to 105 μg/kg. The two patients with a poor response were later discovered to have had unsolved birth canal injuries. No drug-related adverse effects were noted. We recommend that any surgical bleeding should first be controlled, as well as the correction of metabolic and hematological abnormalities; however, in the situation of intractable postpartum hemorrhage, recombinant activated factor VII offers a salvage therapy and should be considered early, even before hysterectomy. ? 2011 The Authors. | en_US |
dc.relation.ispartof | Journal of Obstetrics and Gynaecology Research | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | fresh frozen plasma; methylergometrine; oxytocin; recombinant blood clotting factor 7a; absence of side effects; article; bleeding; chorioamnionitis; clinical article; disease control; disseminated intravascular clotting; drug indication; erythrocyte transfusion; female; human; hysterectomy; maternal morbidity; maternal mortality; medical practice; medical record review; obstetric anesthesia; placenta accreta; postoperative period; postpartum hemorrhage; repeated drug dose; retrospective study; salvage therapy; single drug dose; Taiwan; thrombocyte transfusion; treatment response; university hospital; uterine atony; vaginal delivery; Adult; Anesthesia, Obstetrical; Drug Resistance; Factor VIIa; Hemostatics; Hospitals, University; Humans; Male; Off-Label Use; Postpartum Hemorrhage; Recombinant Proteins; Retrospective Studies; Salvage Therapy; Taiwan; Time Factors; Young Adult | - |
dc.title | Recombinant activated factor VII as a promising adjuvant therapy for postpartum hemorrhage in the practice of obstetric anesthesia: Experience from a university hospital in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/j.1447-0756.2010.01422.x | - |
dc.identifier.pmid | 21736669 | - |
dc.identifier.scopus | 2-s2.0-80052784040 | - |
dc.relation.pages | 901-907 | en_US |
dc.relation.journalvolume | 37 | en_US |
dc.relation.journalissue | 7 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Obstetrics&Gynecology-NTUHHC | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Obstetrics&Gynecology-NTUHHC | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.dept | Traumatology-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.orcid | 0000-0002-0753-2793 | - |
crisitem.author.orcid | 0000-0002-1725-0407 | - |
crisitem.author.orcid | 0000-0002-6849-8453 | - |
crisitem.author.orcid | 0000-0001-8831-7835 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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