https://scholars.lib.ntu.edu.tw/handle/123456789/515736
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | HUANG-CHUN LIEN | en_US |
dc.contributor.author | CHIUN-SHENG HUANG | en_US |
dc.contributor.author | YA-WEN YANG | en_US |
dc.contributor.author | YUNG-MING JENG | en_US |
dc.date.accessioned | 2020-09-30T01:17:17Z | - |
dc.date.available | 2020-09-30T01:17:17Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0903-4641 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/515736 | - |
dc.description.abstract | Spindle neoplasms of the breast (SNB) primarily include metaplastic breast carcinoma (MBC), phyllodes tumour (PT), fibromatosis and primary nonspecific sarcoma (PNS). Mutations in MED12 exon 2 have been reported in PTs. Because spindle tumour components are shared by SNB, we assessed the diagnostic use of MED12 exon 2 mutation in SNB. We investigated MED12 exon 2 mutations in a total of 91 samples of SNB, including 49 PT cases that have been previously analysed. Mutations were identified using direct sequencing. MED12 exon 2 mutation was absent in all cases of MBC, fibromatosis and PNS, in contrast to the 71.4% positivity in PTs. MED12 mutations were identified in four of six previously diagnosed monophasic sarcomatous MCB cases, however, these four cases were revised as malignant PT based on additional bcl-2 staining, albeit very focal. Consistence in the MED12 mutational status between a paired core biopsy and a surgical specimen was observed in all 20 tested PT cases. In conclusion, we demonstrated the restriction of MED12 exon 2 mutation to PTs (73.6%, 39/53) and its absence in other SNB. MED12 exon 2 mutational analysis can be included in the differential diagnosis between PT and other SNB, especially with limited specimen where diagnostic clues are not evident. ? 2016 APMIS Published by John Wiley & Sons Ltd. | - |
dc.relation.ispartof | APMIS | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | CD31 antigen; CD34 antigen; desmin; protein bcl 2; protein S 100; MED12 protein, human; mediator complex; Article; breast biopsy; breast carcinoma; cancer diagnosis; cancer surgery; cystosarcoma phylloides; differential diagnosis; fibromatosis; gene; gene sequence; human; human tissue; major clinical study; MED12 exon 2 gene; metaplastic breast carcinoma; missense mutation; mutational analysis; primary nonspecific sarcoma; priority journal; sarcoma; Breast Neoplasms; DNA sequence; exon; female; genetics; molecular pathology; mutation; pathology; Phyllodes Tumor; procedures; Breast Neoplasms; Diagnosis, Differential; Exons; Female; Humans; Mediator Complex; Mutation; Pathology, Molecular; Phyllodes Tumor; Sequence Analysis, DNA | - |
dc.title | MED12 exon 2 mutation as a highly sensitive and specific marker in distinguishing phyllodes tumours from other spindle neoplasms of the breast | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/apm.12516 | - |
dc.identifier.pmid | 26860948 | - |
dc.identifier.scopus | 2-s2.0-84962798464 | - |
dc.relation.pages | 356-364 | - |
dc.relation.journalvolume | 124 | - |
dc.relation.journalissue | 5 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Traumatology-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.orcid | 0000-0003-1472-1231 | - |
crisitem.author.orcid | 0000-0002-6557-211X | - |
crisitem.author.orcid | 0000-0003-0412-584X | - |
crisitem.author.orcid | 0000-0002-3878-4491 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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