https://scholars.lib.ntu.edu.tw/handle/123456789/515770
Title: | Comparable serologic responses to 2 different combinations of inactivated hepatitis A virus vaccines in HIV-positive patients during an acute hepatitis A outbreak in Taiwan | Authors: | KUAN-YIN LIN SZU-MIN HSIEH WANG-HUEI SHENG Lo Y.-C. YU-CHUNG CHUANG ARISTINE CHENG SUNG-CHING PAN Chen G.-J. HSIN-YUN SUN CHIEN-CHING HUNG SHAN-CHWEN CHANG |
Issue Date: | 2018 | Publisher: | Oxford University Press | Journal Volume: | 218 | Journal Issue: | 5 | Start page/Pages: | 734-738 | Source: | Journal of Infectious Diseases | Abstract: | We evaluated the serologic responses to different 2-dose combinations of the inactivated hepatitis A virus (HAV) vaccines Havrix and Vaqta among human immunodeficiency virus-positive individuals during an acute hepatitis A outbreak in Taiwan. In this 16-month retrospective study, one group received 1 dose of Havrix followed by 1 dose of Vaqta, and another group received 2 doses of Vaqta. The Havrix-Vaqta and Vaqta-Vaqta groups achieved similar seroconversion rates at weeks 28-36 (82.3% and 80.9%, respectively; absolute difference, 1.3% [95% confidence interval {CI}, ?6.3%-3.7%]) and week 48 (94.7% and 94.4%, respectively; absolute difference, 0.3% [95% CI, ?2.6%-3.2%]), suggesting the interchangeability of different combinations of HAV vaccines. The significantly higher seroconversion rate after the first dose of Vaqta, compared with the dose of Havrix (53.0% vs 32.4%) may provide potential benefits in preventing HAV infection during the outbreak. ? The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055442694&doi=10.1093%2finfdis%2fjiy224&partnerID=40&md5=aa4b73b96bace8ee40859e3fd984452b https://scholars.lib.ntu.edu.tw/handle/123456789/515770 |
ISSN: | 0022-1899 | DOI: | 10.1093/infdis/jiy224 | SDG/Keyword: | hepatitis A vaccine; hepatitis A vaccine; hepatitis antibody; inactivated vaccine; adult; Article; CD4 lymphocyte count; comparative study; drug effect; drug efficacy; drug response; epidemic; female; follow up; hepatitis A; human; Human immunodeficiency virus infection; major clinical study; male; priority journal; retrospective study; seroconversion; serology; Taiwan; treatment outcome; vaccination; blood; complication; epidemic; hepatitis A; Human immunodeficiency virus infection; humoral immunity; immunization; immunology; young adult; Adult; Disease Outbreaks; Hepatitis A; Hepatitis A Vaccines; Hepatitis Antibodies; HIV Infections; Humans; Immunity, Humoral; Immunization Schedule; Male; Retrospective Studies; Seroconversion; Taiwan; Treatment Outcome; Vaccines, Inactivated; Young Adult |
Appears in Collections: | 醫學系 |
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