Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. School of Medicine / 醫學系
  4. Potential of stem cell therapy in intracerebral hemorrhage
 
  • Details

Potential of stem cell therapy in intracerebral hemorrhage

Journal
Molecular Biology Reports
Journal Volume
47
Journal Issue
6
Pages
4671-4680
Date Issued
2020
Author(s)
ABEL PO-HAO HUANG  
Hsu, Yi-Hua
Wu, Meng-Shiue
Tsai, Hsin-Han
Su, Chia-Yi
THAI-YEN LING  
SHAN-HUI HSU  
DAR-MING LAI  
DOI
10.1007/s11033-020-05457-9
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084806240&doi=10.1007%2fs11033-020-05457-9&partnerID=40&md5=061692c410fc3e0c53303b56e22eac47
https://scholars.lib.ntu.edu.tw/handle/123456789/516516
Abstract
Spontaneous intracerebral hemorrhage (ICH) is a common disease associated with high mortality and morbidity. The treatment of patients with ICH includes medical and surgical interventions. New areas of surgical intervention have been focused on the evacuation of hematoma through minimally invasive neurosurgery. In contrast, there have been no significant advances in the development of medical interventions for functional recovery after ICH. Stem cells exert multiple therapeutic functions and have emerged as a promising treatment strategy. Herein, we summarized the pathophysiology of ICH and its treatment targets, and we introduced the therapeutic mechanisms of stem cells (e.g. neutrotrophy and neuroregeneration). Moreover, we reviewed and summarized the experimental designs of the preclinical studies, including the types of cells and the timing and routes of stem cell administration. We further listed and reviewed the completed/published and ongoing clinical trials supporting the safety and efficacy of stem cell therapy in ICH. The limitations of translating preclinical studies into clinical trials and the objectives of future studies were discussed. In conclusion, current literatures showed that stem cell therapy is a promising treatment in ICH and further translation research on judiciously selected group of patients is warranted before it can be extensively applied in clinical practice. ? 2020, Springer Nature B.V.
SDGs

[SDGs]SDG3

Other Subjects
adipose derived stem cell; bone marrow derived mesenchymal stem cell; brain hemorrhage; clinical effectiveness; human; induced pluripotent stem cell; intracranial pressure; mesenchymal stem cell; neural stem cell; nonhuman; pathophysiology; prognosis; Review; stem cell transplantation; treatment indication; treatment outcome; umbilical cord; umbilical cord derived mesenchymal stem cell; biological therapy; brain hemorrhage; hematoma; metabolism; procedures; stem cell; stem cell transplantation; Cell- and Tissue-Based Therapy; Cerebral Hemorrhage; Hematoma; Humans; Stem Cell Transplantation; Stem Cells
Publisher
Springer
Type
review

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science