https://scholars.lib.ntu.edu.tw/handle/123456789/516853
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Loh, Julie | en_US |
dc.contributor.author | Chuang, Mei-Chun | en_US |
dc.contributor.author | Lin, Shan-Shan | en_US |
dc.contributor.author | Joseph, Jophin | en_US |
dc.contributor.author | Su, You-An | en_US |
dc.contributor.author | Hsieh, Tsung-Lin | en_US |
dc.contributor.author | Chang, Yu-Chen | en_US |
dc.contributor.author | Liu, Allen P | en_US |
dc.contributor.author | YA-WEN LIU | en_US |
dc.creator | Loh, Julie;Chuang, Mei-Chun;Lin, Shan-Shan;Joseph, Jophin;Su, You-An;Hsieh, Tsung-Lin;Chang, Yu-Chen;Liu, Allen P;Ya-Wen Liu | - |
dc.date.accessioned | 2020-10-13T05:12:38Z | - |
dc.date.available | 2020-10-13T05:12:38Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0021-9533 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/516853 | - |
dc.description.abstract | Internalization of macromolecules and membrane into cells through endocytosis is critical for cellular growth, signaling and plasma membrane (PM) tension homeostasis. Although endocytosis is responsive to both biochemical and physical stimuli, how physical cues modulate endocytic pathways is less understood. Contrary to the accumulating discoveries on the effects of increased PM tension on endocytosis, less is known about how a decrease of PM tension impacts on membrane trafficking. Here, we reveal that an acute decrease of PM tension results in phosphatidic acid (PA) production, F-actin and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2]-enriched dorsal membrane ruffling and subsequent macropinocytosis in myoblasts. The PA production induced by decreased PM tension depends on phospholipase D2 (PLD2) activation via PLD2 nanodomain disintegration. Furthermore, the 'decreased PM tension-PLD2-macropinocytosis' pathway is prominent in myotubes, reflecting a potential mechanism of PM tension homeostasis upon intensive muscle stretching and relaxation. Together, we identify a new mechanotransduction pathway that converts an acute decrease in PM tension into PA production and then initiates macropinocytosis via actin and PI(4,5)P2-mediated processes. | en_US |
dc.language.iso | animation | en_US |
dc.publisher | COMPANY BIOLOGISTS LTD | en_US |
dc.relation.ispartof | Journal of cell science | en_US |
dc.subject | Endocytosis; Mechanical transduction; PLD2 nanodomain; Phosphatidic acid | en_US |
dc.title | An acute decrease in plasma membrane tension induces macropinocytosis via PLD2 activation | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1242/jcs.232579 | - |
dc.identifier.pmid | 31391241 | - |
dc.identifier.isi | WOS:000486214400010 | - |
dc.identifier.url | https://pubmed.ncbi.nlm.nih.gov/31391241/ | - |
dc.relation.journalvolume | 132 | en_US |
dc.relation.journalissue | 17 | en_US |
item.languageiso639-1 | animation | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Molecular Medicine | - |
crisitem.author.orcid | 0000-0003-0180-4142 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 分子醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。