https://scholars.lib.ntu.edu.tw/handle/123456789/516878
Title: | Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis | Authors: | JEN-KUEI PENG Hepgul, Nilay Higginson, Irene J Gao, Wei |
Keywords: | End-stage liver disease; hepatocellular carcinoma; liver cirrhosis; meta-analysis; palliative care; prevalence; quality of life; symptom assessment | Issue Date: | 2019 | Publisher: | SAGE PUBLICATIONS LTD | Journal Volume: | 33 | Journal Issue: | 1 | Start page/Pages: | 24 | Source: | Palliative medicine | Abstract: | Background: End-stage liver disease is a common cause of morbidity and mortality worldwide, yet little is known about its symptomatology and impact on health-related quality of life. Aim: To describe symptom prevalence and health-related quality of life of patients with end-stage liver disease to improve care. Design: Systematic review. Data sources: We searched eight electronic databases from January 1980 to June 2018 for studies investigating symptom prevalence or health-related quality of life of adult patients with end-stage liver disease. No language restrictions were applied. Meta-analyses were performed where appropriate. Results: We included 80 studies: 35 assessing symptom prevalence, 41 assessing health-related quality of life, and 4 both. The instruments assessing symptoms varied across studies. The most frequently reported symptoms were as follows: pain (prevalence range 30%–79%), breathlessness (20%–88%), muscle cramps (56%–68%), sleep disturbance (insomnia 26%–77%, daytime sleepiness 29.5%–71%), and psychological symptoms (depression 4.5%–64%, anxiety 14%–45%). Erectile dysfunction was prevalent (53%–93%) in men. The health-related quality of life of patients with end-stage liver disease was significantly impaired when compared to healthy controls or patients with chronic liver disease. Compared with compensated cirrhosis, decompensation led to significant worsening of both components of the 36-Item Short Form Survey although to a larger degree for the Physical Component Summary score (decrease from average 6.4 (95% confidence interval: 4.0–8.8); p < 0.001) than for the Mental Component Summary score (4.5 (95% confidence interval: 2.4–6.6); p < 0.001). Conclusion: The symptom prevalence of patients with end-stage liver disease resembled that of patients with other advanced conditions. Given the diversity of symptoms and significantly impaired health-related quality of life, multidisciplinary approach and timely intervention are crucial. ? The Author(s) 2018. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/516878 | ISSN: | 0269-2163 1477-030X |
DOI: | 10.1177/0269216318807051 | SDG/Keyword: | adult; Child Pugh score; chronic liver disease; daytime somnolence; disease severity; distress syndrome; dyspnea; end stage liver disease; erectile dysfunction; hospitalization; human; liver cell carcinoma; meta analysis; muscle cramp; prevalence; quality of life; Review; Short Form 36; sleep disorder; systematic review; aged; end stage liver disease; female; liver cirrhosis; male; middle aged; palliative therapy; prevalence; psychology; quality of life; severity of illness index; very elderly; Adult; Aged; Aged, 80 and over; End Stage Liver Disease; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Palliative Care; Prevalence; Quality of Life; Severity of Illness Index |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.