https://scholars.lib.ntu.edu.tw/handle/123456789/516889
標題: | Functional assessment of chronic illness therapy-the fatigue scale exhibits stronger associations with clinical parameters in chronic dialysis patients compared to other fatigue-assessing instruments | 作者: | CHIA-TER CHAO JENQ-WEN HUANG CHIH-KANG CHIANG CHUNG-JEN YEN Hung Y.-C. Hsu S.-H. CHI-YUAN SHIH CHUN-FU LAI DING-CHENG CHAN KUAN-YU HUNG TZONG-SHINN CHU Huang S.-J. COGENT (COhort of GEriatric Nephrology in NTUH) study group |
公開日期: | 2016 | 出版社: | PeerJ Inc. | 卷: | 2016 | 期: | 3 | 起(迄)頁: | e1818 | 來源出版物: | PeerJ | 摘要: | Background. Patients with end-stage renal disease (ESRD) have a high symptom burden, among which fatigue is highly prevalent. Many fatigue-assessing instruments exist, but comparisons among instruments in this patient population have yet to be investigated. Methods. ESRD patients under chronic hemodialysis were prospectively enrolled and seven types of fatigue instruments were administered: Brief Fatigue Inventory (BFI), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), Fatigue Severity Scale (FSS), Lee Fatigue Scale (LFS), Fatigue Questionnaire (FQ), Fatigue Symptom Inventory (FSI), and Short-Form 36-Vitality (SF36-V). Using these instruments, we investigated the correlation between fatigue severity and clinical/biochemical parameters, including demographic/comorbidity profile, dialysis-related complications, and frailty severity. We used regression analysis with serum albumin and frailty severity as the dependent variables to investigate the independent correlations. Results. A total of 46 ESRD patients were enrolled (average age of 67 ± 11.6 years), and 50% of them had type 2 diabetes mellitus. Results from the seven tested instruments showed high correlation with each other. We found that the fatigue severity by FACIT-F was significantly associated with age (p = 0.03), serum albumin (p = 0.003) and creatinine (p = 0.02) levels, while SF36-V scores were also significantly associated with age (p = 0.02) and serum creatinine levels (p = 0.04). However, the fatigue severity measured by the FSS, FSI, FQ, BFI, and LFS did not exhibit these associations. Moreover, regression analysis showed that only FACIT-F scores were independently associated with serum albumin levels and frailty severity in ESRD patients. Conclusion. Among the seven fatigue-assessing instruments, only the FACIT-F yielded results that demonstrated significant and independent associations with important outcome-related features in ESRD patients. ? 2016 Chao et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84963983870&doi=10.7717%2fpeerj.1818&partnerID=40&md5=e801d3d8ef548aa6f1f95cb6def80b14 https://scholars.lib.ntu.edu.tw/handle/123456789/516889 |
ISSN: | 2167-8359 | DOI: | 10.7717/peerj.1818 | SDG/關鍵字: | albumin; creatinine; potassium; age; aged; Article; Brief Fatigue Inventory; chronic disease; clinical article; clinical feature; comparative study; diabetic nephropathy; disease severity; end stage renal disease; fatigue; Fatigue Questionnaire; Fatigue Severity Scale; Fatigue Symptom Inventory; female; frail elderly; Functional Assessment of Chronic Illness Therapy Fatigue; functional status assessment; hemodialysis; human; Lee Fatigue Scale; male; non insulin dependent diabetes mellitus; prospective study; Short Form 36; urea nitrogen blood level |
顯示於: | 醫學系 |
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