|Title:||Increased risk of arrhythmia in patients with psoriatic disease: A nationwide population-based matched cohort study||Authors:||Chiu H.-Y.
|Issue Date:||2015||Publisher:||Mosby Inc.||Journal Volume:||73||Journal Issue:||3||Start page/Pages:||429-438||Source:||Journal of the American Academy of Dermatology||Abstract:||
Background Psoriasis is associated with cardiovascular morbidity and mortality. However, the association between psoriasis and arrhythmia has not been adequately studied. Objective We sought to investigate whether patients with psoriasis have an increased risk of arrhythmia. Methods This population-based cohort study identified 40,637 patients with psoriasis and 162,548 subjects without psoriasis matched by age, sex, history of coronary artery disease, hypertension, and diabetes in the Taiwan National Health Insurance Research Database during 2004 through 2006. Results After adjusting for medical history and medication use, patients with psoriasis were at increased risk of overall arrhythmia (adjusted hazard ratio [aHR] 1.34; 95% confidence interval [CI] 1.29-1.39). The risks of arrhythmia were higher in all subgroups, including patients with severe (aHR 1.25; 95% CI 1.12-1.39) and mild (aHR 1.35; 95% CI 1.30-1.41) psoriasis, and in patients with (aHR 1.46; 95% CI 1.22-1.74) and without (aHR 1.33; 95% CI 1.28-1.39) psoriatic arthritis. Limitations The National Health Insurance Research Database did not contain information regarding Psoriasis Area and Severity Index, cigarette smoking, or alcohol consumption. Conclusion Patients with psoriasis were at higher risk of developing arrhythmia, particularly for those with psoriatic arthritis, independent of traditional cardiovascular risk factors. ? 2015 American Academy of Dermatology, Inc.
|ISSN:||0190-9622||DOI:||10.1016/j.jaad.2015.06.023||metadata.dc.subject.other:||adult; age distribution; ambulatory care; Article; cardiovascular mortality; cardiovascular risk; cerebrovascular accident; chronic obstructive lung disease; cohort analysis; controlled study; coronary artery disease; coronary risk; diabetes mellitus; disease association; female; heart arrhythmia; heart failure; human; hyperlipidemia; hypertension; ICD-9-CM; kidney disease; major clinical study; male; medical history; morbidity; obesity; paroxysmal supraventricular tachycardia; pharmaceutical care; phototherapy; priority journal; psoriasis; psoriatic arthritis; sleep disordered breathing; sudden death; systemic therapy; thyroid disease; aged; Arrhythmias, Cardiac; Arthritis, Psoriatic; Cardiovascular Diseases; case control study; comparative study; complication; confidence interval; electrocardiography; factual database; incidence; middle aged; pathophysiology; procedures; prognosis; proportional hazards model; psoriasis; retrospective study; risk assessment; severity of illness index; sex ratio; survival rate; Taiwan; Adult; Age Distribution; Aged; Arrhythmias, Cardiac; Arthritis, Psoriatic; Cardiovascular Diseases; Case-Control Studies; Confidence Intervals; Databases, Factual; Electrocardiography; Female; Humans; Incidence; Male; Middle Aged; Prognosis; Proportional Hazards Models; Psoriasis; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Distribution; Survival Rate; Taiwan
|Appears in Collections:||醫學系|
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