https://scholars.lib.ntu.edu.tw/handle/123456789/518178
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hsu W.-L. | en_US |
dc.contributor.author | Chien Y.-C. | en_US |
dc.contributor.author | Huang Y.-T. | en_US |
dc.contributor.author | Yu K.J. | en_US |
dc.contributor.author | JENG-YUH KO | en_US |
dc.contributor.author | Lin C.-Y. | en_US |
dc.contributor.author | Tsou Y.-A. | en_US |
dc.contributor.author | Leu Y.-S. | en_US |
dc.contributor.author | Liao L.-J. | en_US |
dc.contributor.author | Chang Y.-L. | en_US |
dc.contributor.author | Su J.-Y. | en_US |
dc.contributor.author | Liu Z. | en_US |
dc.contributor.author | CHENG-PING WANG | en_US |
dc.contributor.author | Terng S.-D. | en_US |
dc.contributor.author | Hua C.-H. | en_US |
dc.contributor.author | Lee J.-C. | en_US |
dc.contributor.author | TSUNG-LIN YANG | en_US |
dc.contributor.author | Kate Hsiao C.-H. | en_US |
dc.contributor.author | MING-SHIANG WU | en_US |
dc.contributor.author | Tsai M.-H. | en_US |
dc.contributor.author | Liu M.-J. | en_US |
dc.contributor.author | PEI-JEN LOU | en_US |
dc.contributor.author | Hildesheim A. | en_US |
dc.contributor.author | Chen C.-J. | en_US |
dc.contributor.author | the GEV-NPC Study Group | en_US |
dc.creator | Hsu W.-L;Chien Y.-C;Huang Y.-T;Yu K.J;Ko J.-Y;Lin C.-Y;Tsou Y.-A;Leu Y.-S;Liao L.-J;Chang Y.-L;Su J.-Y;Liu Z;Wang C.-P;Terng S.-D;Hua C.-H;Lee J.-C;Yang T.-L;Kate Hsiao C.-H;Wu M.-S;Tsai M.-H;Liu M.-J;Pei-Jen Lou;Hildesheim A;Chen C.-J;The Gev-Npc Study Group | - |
dc.date.accessioned | 2020-10-27T12:04:10Z | - |
dc.date.available | 2020-10-27T12:04:10Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2045-7634 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079141181&doi=10.1002%2fcam4.2832&partnerID=40&md5=2f89d40bfa2da5fadd274cefdfd94180 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/518178 | - |
dc.description.abstract | Background: The study aims are to evaluate the associations between nasopharyngeal carcinoma (NPC) risk and cigarette smoking and to explore the effects of cigarette smoking on Epstein-Barr virus (EBV) infection for NPC risk. Methods: 1235 male NPC cases and 1262 hospital-based male controls matched to cases were recruited across six collaborative hospitals between 2010 and 2014. Using a standardized questionnaire, information on cigarette smoking and other potential risk factors for NPC was obtained. Blood was collected and used for anti-EBV VCA IgA and anti-EBV EA-EBNA1 IgA testing using standard methods. Unconditional logistic regression analysis was used to estimate odds ratio (OR) with 95% confidence interval (CI) for each risk factor after adjusting for confounders. Results: 63.6% of cases and 44.0% of controls reported ever smoking cigarettes. After full adjustment, current smokers had a significant 1.60-fold (95% CI?=?1.30-1.97) and former smokers a borderline significant 1.27-fold (95% CI?=?1.00-1.60) increased NPC risk compared to never smokers. NPC risk increased with increasing duration, intensity, and pack-years of cigarette smoking but not with age at smoking initiation. Among controls, anti-EBV VCA IgA seropositivity rate was higher in current smokers than never smokers (14.0% vs 8.4%; OR?=?1.82; 95% CI?=?1.19-2.79). Mediation analyses showed that more than 90% of the cigarette smoking effect on NPC risk is mediated through anti-EBV VCA IgA. Conclusion: This study confirms the association between long-term cigarette smoking and NPC and demonstrates that current smoking is associated with seropositivity of anti-EBV VCA IgA antibodies. ? 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. | en_US |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.relation.ispartof | Cancer Medicine | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Epstein Barr virus antigen; immunoglobulin A antibody; capsid protein; Epstein-Barr viral capsid antigen; immunoglobulin A; virus antibody; virus antigen; adult; age; aged; antibody response; Article; blood sampling; cancer risk; case control study; cigarette smoking; controlled study; Coombs test; current smoker; disease association; disease duration; disease severity; Epstein Barr virus infection; ex-smoker; hospital based case control study; human; immunomodulation; information processing; major clinical study; male; middle aged; nasopharynx carcinoma; never smoker; priority journal; questionnaire; retrospective study; risk assessment; risk factor; smoking; Taiwan; adverse event; blood; cigarette smoking; clinical trial; Epstein Barr virus; Epstein Barr virus infection; immunology; isolation and purification; multicenter study; nasopharynx carcinoma; nasopharynx tumor; procedures; virology; Adult; Aged; Antibodies, Viral; Antigens, Viral; Capsid Proteins; Case-Control Studies; Cigarette Smoking; Epstein-Barr Virus Infections; Ex-Smokers; Herpesvirus 4, Human; Humans; Immunoglobulin A; Male; Mediation Analysis; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Non-Smokers; Risk Assessment; Risk Factors; Smokers; Taiwan | - |
dc.title | Cigarette smoking increases the risk of nasopharyngeal carcinoma through the elevated level of IgA antibody against Epstein-Barr virus capsid antigen: A mediation analysis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/cam4.2832 | - |
dc.identifier.pmid | 31925935 | - |
dc.identifier.scopus | 2-s2.0-85079141181 | - |
dc.relation.pages | 1867-1876 | en_US |
dc.relation.journalvolume | 9 | en_US |
dc.relation.journalissue | 5 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.orcid | 0000-0002-2538-558X | - |
crisitem.author.orcid | 0000-0001-7872-1463 | - |
crisitem.author.orcid | 0000-0001-6521-8631 | - |
crisitem.author.orcid | 0000-0002-1940-6428 | - |
crisitem.author.orcid | 0000-0002-3383-8593 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學系 |
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