https://scholars.lib.ntu.edu.tw/handle/123456789/518234
標題: | Molecular characterization of photosensitizer-mediated photodynamic therapy by gene expression profiling | 作者: | Liu K.-H CHENG-PING WANG Chang M.-F Chung Y.-W PEI-JEN LOU Lin J.-H. |
公開日期: | 2014 | 出版社: | SAGE Publications Inc. | 卷: | 33 | 期: | 6 | 起(迄)頁: | 629-637 | 來源出版物: | Human and Experimental Toxicology | 摘要: | Photodynamic therapy (PDT) is a novel cancer treatment based on the tumor-specific accumulation of a photosensitizer followed by irradiation with visible light, which induces selective tumor cell death via production of reactive oxygen species. To elucidate the underlying mechanisms, microarray analysis was used to analyze the changes in gene expression patterns during PDT induced by various photosensitizers. Cancer cells were subjected to four different photosensitizer-mediated PDT and the resulting gene expression profiles were compared. We identified many differentially expressed genes reported previously as well as new genes for which the functionfunctions in PDT are still unclear. Our current results not only advance the general understanding of PDT but also suggest that distinct molecular mechanisms are involved in different photosensitizer-mediated PDT. Elucidating the signaling mechanisms in PDT will provide information to modulate the antitumor effectiveness of PDT using various photosensitizers. ? 2014 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901442544&doi=10.1177%2f0960327113485257&partnerID=40&md5=319e5d00716c958050bea1dc137f2769 https://scholars.lib.ntu.edu.tw/handle/123456789/518234 |
ISSN: | 0960-3271 | DOI: | 10.1177/0960327113485257 | SDG/關鍵字: | aminolevulinic acid; apoptotic protease activating factor 1; caspase 4; disulfonated aluminium phthalocyanine; dual specificity phosphatase 6; ephrin B2; growth differentiation factor 15; interleukin 8; low density lipoprotein receptor; meso tetraphenylporphyrin disulfonate; photosensitizing agent; phthalocyanine derivative; stromelysin 2; sulfonic acid derivative; temoporfin; transcription factor FosB; unclassified drug; photosensitizing agent; antineoplastic activity; apoptosis; apoptotic protease activating factor 1 gene; article; cancer chemotherapy; caspase 4 gene; cell survival; controlled study; drug cytotoxicity; drug mechanism; dual specificity phosphatase 6 gene; ephrin B2 gene; Fosb gene; gene; gene expression profiling; growth differentiation factor 15 gene; human; human cell; interleukin 8 gene; low density lipoprotein receptor gene; microarray analysis; mouth squamous cell carcinoma; oncogene c fos; photodynamic therapy; phototoxicity; priority journal; prostaglandin endoperoxide synthase 2 gene; Ras homolog enriched in brain like 1 gene; retinoic acid induced 3 gene; serpinb2 gene; signal transduction; squamous cell carcinoma cell line; stromelysin 2 gene; survival rate; DNA microarray; drug effects; gene expression profiling; gene expression regulation; genetics; head and neck tumor; mouth tumor; pathology; photochemotherapy; procedures; real time polymerase chain reaction; reproducibility; reverse transcription polymerase chain reaction; squamous cell carcinoma; time; tumor cell line; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Mouth Neoplasms; Oligonucleotide Array Sequence Analysis; Photochemotherapy; Photosensitizing Agents; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Time Factors |
顯示於: | 醫學系 |
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