Intracranial relapse of nasopharyngeal carcinoma manifested as sudden deafness
Journal
Otology and Neurotology
Journal Volume
22
Journal Issue
3
Pages
392-396
Date Issued
2001
Author(s)
Abstract
Objective: To differentiate tumor relapse from postirradiation sudden deafness (PISD) in patients with nasopharyngeal carcinoma (NPC). Study Design: A retrospective study from December 1991 to November 1999. Setting: University hospital. Patients: Twenty-five irradiated NPC patients with sudden deafness were investigated. All patients received local examination of ears, nose, nasopharynx, and throat fields, as well as a battery of audiologic and neurotologic tests. Results: Three patients with sudden deafness within 3 years after irradiation received a diagnosis of tumor relapse. Magnetic resonance imaging revealed cerebellopontine angle metastasis in one and intracranial invasion in two. Comparison of the remaining 22 NPC patients who had PISD showed that the mean interval between the completion of irradiation to the onset of sudden deafness was 10 ± 5 years. Conclusion: Magnetic resonance imaging should be performed to exclude intracranial relapse if sudden deafness develops in a patient with NPC within 5 years after irradiation.
Subjects
Cerebellopontine angle tumor; Intracranial invasion; Irradiation; Nasopharyngeal carcinoma; Sudden deafness
SDGs
Other Subjects
adult; aged; article; brain metastasis; cancer invasion; cancer radiotherapy; clinical article; female; human; male; nasopharynx carcinoma; nuclear magnetic resonance imaging; pons angle tumor; priority journal; relapse; sudden deafness
Publisher
Lippincott Williams and Wilkins
Type
journal article