https://scholars.lib.ntu.edu.tw/handle/123456789/519476
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yang S.-Y. | en_US |
dc.contributor.author | Weng P.-H. | en_US |
dc.contributor.author | JEN-HAU CHEN | en_US |
dc.contributor.author | Chiou J.-M. | en_US |
dc.contributor.author | Lew-Ting C.-Y. | en_US |
dc.contributor.author | TA-FU CHEN | en_US |
dc.contributor.author | Sun Y. | en_US |
dc.contributor.author | Wen L.-L. | en_US |
dc.contributor.author | Yip P.-K. | en_US |
dc.contributor.author | Chu Y.-M. | en_US |
dc.contributor.author | YEN-CHING CHEN | en_US |
dc.creator | Yang S.-Y.;Weng P.-H.;Chen J.-H.;Chiou J.-M.;Lew-Ting C.-Y.;Ta-Fu Chen;Sun Y.;Wen L.-L.;Yip P.-K.;Chu Y.-M.;Chen Y.-C. | - |
dc.date.accessioned | 2020-11-03T11:20:35Z | - |
dc.date.available | 2020-11-03T11:20:35Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0929-6646 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85000096302&doi=10.1016%2fj.jfma.2014.09.006&partnerID=40&md5=a08062d20bd9e23d1d089158419f9d53 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/519476 | - |
dc.description.abstract | Background/Purpose: Leisure activities have been associated with a decreased risk of dementia. However, to date, no study has explored how apolipoprotein E (. ApoE) e4 status or vascular risk factors modified the association between leisure activities and dementia risks. Methods: This case-control study recruited patients (age ? 60 years) with Alzheimer's disease (AD; n = 292) and vascular dementia (VaD; n = 144) and healthy controls (. n = 506) from three teaching hospitals in Taiwan between 2007 and 2010. Information on patient's leisure activities were obtained through a questionnaire. Conditional logistic regression models were used to assess the association of leisure activities and ApoE e4 status with the risk of dementia. Results: High-frequency physical activity was associated with a decreased risk of AD [adjusted odds ratio (AOR) = 0.45], and the results become more evident among ApoE e4 carriers with AD (AOR = 0.30) and VaD (AOR = 0.26). Similar findings were observed for cognitive (AOR = 0.42) and social activities (AOR = 0.55) for AD. High-frequency physical, cognitive, and social activities were associated with a decreased risk of VaD (AOR = 0.29-0.60). Physical and social activities significantly interacted with each other on the risk of VaD (pinteraction = 0.04). Conclusion: Physical activity consistently protects against AD and VaD. Significant interactions were identified across different types of leisure activities in lowering dementia risk. ? 2014. | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.ispartof | Journal of the Formosan Medical Association | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | apolipoprotein E4; apolipoprotein E4; genetic marker; aged; Alzheimer disease; Article; controlled study; female; human; leisure; major clinical study; male; multiinfarct dementia; physical activity; risk factor; social behavior; Taiwan; Alzheimer disease; case control study; clinical trial; genetic marker; genetics; heterozygote; motor activity; multicenter study; odds ratio; questionnaire; statistical model; very elderly; Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Case-Control Studies; Female; Genetic Markers; Heterozygote; Humans; Leisure Activities; Logistic Models; Male; Motor Activity; Odds Ratio; Risk Factors; Surveys and Questionnaires; Taiwan | - |
dc.title | Leisure activities, apolipoprotein E e4 status, and the risk of dementia | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jfma.2014.09.006 | - |
dc.identifier.pmid | 25457293 | - |
dc.identifier.scopus | 2-s2.0-85000096302 | - |
dc.relation.pages | 1216-1224 | - |
dc.relation.journalvolume | 114 | - |
dc.relation.journalissue | 12 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Geriatrics and Gerontology-NTUH | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | The Clinical Center for Neuroscience and Behavior | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.orcid | 0000-0003-1988-6924 | - |
crisitem.author.orcid | 0000-0002-8159-7202 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
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