https://scholars.lib.ntu.edu.tw/handle/123456789/519493
DC 欄位 | 值 | 語言 |
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dc.contributor.author | YEN-CHING CHEN | en_US |
dc.contributor.author | Yip P.-K. | en_US |
dc.contributor.author | Huang Y.-L. | en_US |
dc.contributor.author | Sun Y. | en_US |
dc.contributor.author | Wen L.-L. | en_US |
dc.contributor.author | Chu Y.-M. | en_US |
dc.contributor.author | TA-FU CHEN | en_US |
dc.creator | Chen Y.-C.;Yip P.-K.;Huang Y.-L.;Sun Y.;Wen L.-L.;Chu Y.-M.;Ta-Fu Chen | - |
dc.date.accessioned | 2020-11-03T11:20:39Z | - |
dc.date.available | 2020-11-03T11:20:39Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84871296103&doi=10.1371%2fjournal.pone.0050771&partnerID=40&md5=593fc985b3e214046c2f06c81c052bdc | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/519493 | - |
dc.description.abstract | Background: Toll like receptor 4 (TLR4) has been related to inflammation and beta-amyloid deposition in Alzheimer's disease (AD) brain. No study has explored the association between haplotype-tagging single nucleotide polymorphisms (htSNPs) of TLR4 and AD risk previously and ApoE e4 status alone showed low sensitivity in identifying late-onset AD (LOAD) patients. Methods: A total of 269 LOAD patients were recruited from three hospitals in northern Taiwan (2007-2010). Controls (n = 449) were recruited from elderly health checkup and volunteers of the hospital during the same period of time. Five common (frequency?5%) TLR4 htSNPs were selected to assess the association between TLR4 polymorphisms and the risk of LOAD in the Chinese ethnic population. Results: Homozygosity of TLR4 rs1927907 was significantly associated with an increased risk of LOAD [TT vs. CC: adjusted odds ratio (AOR) = 2.45, 95% confidence interval (CI) = 1.30-4.64]. After stratification, the association increased further in ApoE e4 non-carriers (AOR = 3.07) and in hypertensive patients (AOR = 3.60). Haplotype GACGG was associated with a decreased risk of LOAD (1 vs. 0 copies: AOR = 0.59, 95% CI = 0.36-0.96; 2 vs. 0 copies: AOR = 0.31, 95% CI = 0.14-0.67) in ApoE e4 non-carriers. ApoE e4 status significantly modified this association (pinteraction = 0.01). These associations remained significant after correction for multiple tests. Conclusions: Sequence variants of TLR4 were associated with an increased risk of LOAD, especially in ApoE e4 non-carriers and in hypertensive patients. The combination of TLR4 rs1927907 and ApoE e4 significantly increased the screening sensitivity in identifying LOAD patients from 0.4 to 0.7. ? 2012 Chen et al. | - |
dc.relation.ispartof | PLoS ONE | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | apolipoprotein E4; toll like receptor 4; aged; Alzheimer disease; article; Chinese; controlled study; female; gene; gene frequency; genotype; haplotype; homozygosity; human; hypercholesterolemia; hypertension; major clinical study; male; non insulin dependent diabetes mellitus; population research; risk assessment; risk factor; single nucleotide polymorphism; TLR4 gene; Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Case-Control Studies; Dementia; Female; Genetic Linkage; Genotype; Haplotypes; Heterozygote; Homozygote; Humans; Hypertension; Inflammation; Male; Models, Genetic; Odds Ratio; Polymorphism, Single Nucleotide; Questionnaires; Risk; Taiwan; Toll-Like Receptor 4 | - |
dc.title | Sequence Variants of Toll Like Receptor 4 and Late-Onset Alzheimer's Disease | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1371/journal.pone.0050771 | - |
dc.identifier.pmid | 23272070 | - |
dc.identifier.scopus | 2-s2.0-84871296103 | - |
dc.relation.pages | e50771 | - |
dc.relation.journalvolume | 7 | - |
dc.relation.journalissue | 12 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | The Clinical Center for Neuroscience and Behavior | - |
crisitem.author.orcid | 0000-0002-8159-7202 | - |
crisitem.author.orcid | 0000-0003-1988-6924 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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