https://scholars.lib.ntu.edu.tw/handle/123456789/520010
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Cheng Y.-C. | en_US |
dc.contributor.author | Lin H.-I. | en_US |
dc.contributor.author | Syu S.-H. | en_US |
dc.contributor.author | Lu H.-E. | en_US |
dc.contributor.author | Huang C.-Y. | en_US |
dc.contributor.author | CHIN-HSIEN LIN | en_US |
dc.contributor.author | Hsieh P.C.H. | en_US |
dc.creator | Cheng Y.-C.;Lin H.-I.;Syu S.-H.;Lu H.-E.;Huang C.-Y.;Chin-Hsien Lin;Hsieh P.C.H. | - |
dc.date.accessioned | 2020-11-03T12:12:38Z | - |
dc.date.available | 2020-11-03T12:12:38Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1873-5061 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063937507&doi=10.1016%2fj.scr.2019.101432&partnerID=40&md5=bc20ab82c91477708cfd4c6a7f4c9edb | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/520010 | - |
dc.description.abstract | A recessive mutation in PLA2G6, which is known to cause a heterogeneous neurodegenerative clinical spectrum, has recently been shown to be responsible for autosomal-recessive familial forms of Parkinson's disease (PD). Here, we generated induced pluripotent stem cells (iPSCs) from the peripheral blood mononuclear cells of a female patient with a homozygous PLA2G6 c.991G > T (p.D331Y) mutation by using the Sendai-virus delivery system. The resulting iPSCs showed pluripotency confirmed by immunofluorescent staining for pluripotency markers and differentiated into the 3 germ layers in vivo. This cellular model will provide a good resource for further pathophysiological studies of PD. ? 2019 | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.ispartof | Stem Cell Research | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alpha smooth muscle actin; phospholipase A2 group VI; phospholipase A2 group VI; PLA2G6 protein, human; Article; cell differentiation; chromosome analysis; controlled study; flow cytometry; gene mutation; germ layer; human; human cell; immunocytochemistry; immunofluorescence test; in vivo study; induced pluripotent stem cell; karyotyping; Mycoplasma; nuclear reprogramming; Parkinson disease; pathophysiology; peripheral blood mononuclear cell; priority journal; Sanger sequencing; Southern blotting; adult; animal; cell culture; cell differentiation; female; genetics; homozygote; induced pluripotent stem cell; metabolism; mononuclear cell; mouse; mutation; nonobese diabetic mouse; onset age; Parkinson disease; pathology; phenotype; SCID mouse; teratoma; Adult; Age of Onset; Animals; Cell Differentiation; Cells, Cultured; Cellular Reprogramming; Female; Group VI Phospholipases A2; Homozygote; Humans; Induced Pluripotent Stem Cells; Leukocytes, Mononuclear; Mice; Mice, Inbred NOD; Mice, SCID; Mutation; Parkinson Disease; Phenotype; Teratoma | - |
dc.title | Reprogramming of a human induced pluripotent stem cell (iPSC) line (IBMSi012-A) from an early-onset Parkinson's disease patient harboring a homozygous p.D331Y mutation in the PLA2G6 gene | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.scr.2019.101432 | - |
dc.identifier.pmid | 30978640 | - |
dc.identifier.scopus | 2-s2.0-85063937507 | - |
dc.relation.journalvolume | 37 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | The Clinical Center for Neuroscience and Behavior | - |
crisitem.author.orcid | 0000-0001-8566-7573 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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