https://scholars.lib.ntu.edu.tw/handle/123456789/520023
標題: | Generation of induced pluripotent stem cells from a patient with Parkinson's disease carrying LRRK2 p.I2012T mutation | 作者: | CHIN-HSIEN LIN Cheng Y.-C. Lin H.-I. Ho M.-C. Hsu Y.-H. Wen C.-H. Ko H.-W. Lu H.-E. Huang C.-Y. Hsieh P.C.H. |
公開日期: | 2017 | 出版社: | Elsevier B.V. | 卷: | 25 | 起(迄)頁: | 123-127 | 來源出版物: | Stem Cell Research | 摘要: | Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by interactions between genetic and environmental factors. Leucine rich repeat kinase (LRRK2) is the most prevalent mutation in autosomal-dominant inheritance of PD. Here, we generated induced pluripotent stem cells (iPSCs) from the peripheral blood mononuclear cells of a female patient with p.I2012T mutation in LRRK2 gene by using the Sendai-virus delivery system. The resulting iPSCs had a normal karyotype. The iPSCs also showed pluripotency confirmed by immunofluorescent staining and differentiated into the 3 germ layers in vivo. This cellular model will provide a useful platform for further pathophysiological studies of PD. ? 2017 The Authors |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032973769&doi=10.1016%2fj.scr.2017.10.020&partnerID=40&md5=b94f63af6401b81a7b4fdd9b026706f6 https://scholars.lib.ntu.edu.tw/handle/123456789/520023 |
ISSN: | 1873-5061 | DOI: | 10.1016/j.scr.2017.10.020 | SDG/關鍵字: | genomic DNA; leucine rich repeat kinase 2; leucine rich repeat kinase 2; Article; case report; cell differentiation; clinical article; female; gene mutation; genetic stability; human; human cell; human tissue; induced pluripotent stem cell; karyotype; karyotyping; Parkinson disease; peripheral blood mononuclear cell; priority journal; Sendai virus; cytology; genetics; induced pluripotent stem cell; metabolism; mutation; Parkinson disease; Female; Humans; Induced Pluripotent Stem Cells; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mutation; Parkinson Disease |
顯示於: | 醫學系 |
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