https://scholars.lib.ntu.edu.tw/handle/123456789/520109
標題: | Complications of erythropoietin in navigated brain gene therapy: A case report | 作者: | SHENG-HONG TSENG CHUN-HWEI TAI WUH-LIANG HWU |
公開日期: | 2020 | 出版社: | Elsevier B.V. | 卷: | 21 | 起(迄)頁: | 100698 | 來源出版物: | Interdisciplinary Neurosurgery: Advanced Techniques and Case Management | 摘要: | Erythropoietin has been used to treat brain injuries and increase preoperative hemoglobin levels. A seven-year-old boy presented with aromatic L-amino acid decarboxylase deficiency, an enzyme responsible for producing dopamine and serotonin. He received gene therapy through an injection of adeno-associated viral vectors to the bilateral putamen, but not to the brain stem where serotoninergic neurons reside. An erythropoiesis-stimulating agent was given before surgery to increase his preoperative hemoglobin level. Unexpectedly, in preoperative planning, prominent cerebral vasculatures were visualized on magnetic resonance imaging. One month later, symptoms of serotonin overproduction, including vomiting, diarrhea, and high fever presented, which lead to dehydration and shock. We speculated that the viral vector spread from the putamen through the proliferating vasculature to the brain stem, causing the complication. ? 2020 The Authors |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081001239&doi=10.1016%2fj.inat.2020.100698&partnerID=40&md5=204098d283cfaf1efa274eff27f3016a https://scholars.lib.ntu.edu.tw/handle/123456789/520109 |
ISSN: | 2214-7519 | DOI: | 10.1016/j.inat.2020.100698 | SDG/關鍵字: | adeno associated virus vector; aromatic levo amino acid decarboxylase; gelfoam; hemoglobin; recombinant erythropoietin; serotonin; surgical glue; adverse event; anemia; aromatic levo amino acid decarboxylase deficiency; Article; body temperature; brain blood vessel; brain hemorrhage; brain injury; cardiopulmonary insufficiency; case report; child; clinical article; clinical trial (topic); dehydration; diarrhea; enzyme deficiency; feeding difficulty; fever; hemoglobin blood level; hospital discharge; human; hypovolemic shock; male; neuroimaging; nuclear magnetic resonance imaging; nutritional status; positron emission tomography; preoperative period; priority journal; putamen; resuscitation; school child; serotonin release; side effect; sweating; treatment planning; viral gene therapy; vomiting |
顯示於: | 醫學系 |
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