https://scholars.lib.ntu.edu.tw/handle/123456789/520124
標題: | The impact of nonmotor symptoms on quality of life in patients with parkinson's disease in Taiwan | 作者: | Liu W.-M. Lin R.-J. Yu R.-L. CHUN-HWEI TAI CHIN-HSIEN LIN RUEY-MEEI WU |
公開日期: | 2015 | 出版社: | Dove Medical Press Ltd. | 卷: | 11 | 起(迄)頁: | 2865-2873 | 來源出版物: | Neuropsychiatric Disease and Treatment | 摘要: | Purpose: The nonmotor symptoms (NMS) of Parkinson’s disease (PD) are important factors for quality of life (QoL). Few studies on NMS have been conducted in Asian PD patients. Additionally, effects of anti-PD drugs on risk of NMS are still controversial. We therefore conducted this hospital-based cross-sectional study to examine the clinical factors, including concomitant anti-PD medication use, on the occurrence of NMS and QoL in Taiwanese PD patients. Patients and methods: PD patients who received long-term follow-up in the movement disorders clinics were enrolled and received NMS questionnaire (NMSQuest) and the 39-item Parkinson’s Disease Questionnaire (PDQ-39). Spearman’s rank correlation coefficient was checked for the correlation between clinical factors and NMSQT/PDQSI. Multiple linear regressions were applied to assess the influence of clinical factors on NMSQT/PDQSI. Results: A total of 210 PD patients (mean age 66.1±9.86 years, Hoehn and Yahr stage 2.2±0.9) were included in this study. Up to 98% of patients reported at least one symptom of NMS. The most prevalent symptom was urinary complaints (56%), followed by memory/apathy (30%) and depression/anxiety (28%). The correlation between NMSQT and PDQSI was strong (rs=0.667), especially the item of depression/anxiety (rs=0.607). The regression model for NMSQT indicated that disease duration and severity, but not pharmacological therapy, were major predictors of NMS. Conclusion: Our data indicated a high prevalence rate of NMS in PD patients. Among symptoms of NMS, depression and anxiety had the greatest impact on QoL. Concomitant anti-PD medication use did not affect the occurrence of NMS and QoL. ? 2015 Liu et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84947076382&doi=10.2147%2fNDT.S88968&partnerID=40&md5=46b1756ba91e1f92719ff7a7cebe0a6b https://scholars.lib.ntu.edu.tw/handle/123456789/520124 |
ISSN: | 1176-6328 | DOI: | 10.2147/NDT.S88968 | SDG/關鍵字: | levodopa; adult; aged; anxiety; apathy; Article; constipation; cross-sectional study; depression; disease association; disease duration; disease severity; drug use; feces incontinence; female; Hoehn and Yahr scale; human; major clinical study; male; memory disorder; nocturia; nonmotor symptom; nonmotor symptom questionnaire; Parkinson disease; Parkinson Disease Questionnaire 39; predictive value; prevalence; quality of life; questionnaire; risk factor; sex difference; sexual dysfunction; symptom; Taiwan; urinary complaint; urinary dysfunction |
顯示於: | 醫學系 |
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