https://scholars.lib.ntu.edu.tw/handle/123456789/520496
標題: | Long-term statin use and dementia risk in Taiwan | 作者: | Chen P.-Y. Liu S.-K. Chen C.-L. CHI-SHIN WU |
關鍵字: | dementia; epidemiology; pharmacotherapy | 公開日期: | 2014 | 卷: | 27 | 期: | 3 | 起(迄)頁: | 165-171 | 來源出版物: | Journal of Geriatric Psychiatry and Neurology | 摘要: | Background: The effect of statin use on dementia risk remains unclear. This study aims to examine the association between long-term statin use and dementia risk. Methods: A nest case-control study within a nationwide representative populationbased cohort. Individuals aged 50 years and older participating in Taiwan's National Health Insurance program between 1998 and 2009 were enrolled. A total of 9257 patients with at least 3 outpatient or 1 inpatient claims records for dementia were identified. Comparison patients were selected at a 1:2 ratio from age- and sex-matched participants without dementia. The cumulative period and average daily dosages of statins, fibrates, and other lipid-lowering agents were measured. Results: The authors found a duration-response relationship, as dementia risk decreased by 9% per year of treatment of statins (adjusted odds ratio 0.91; 95% confidence interval, 0.85-0.97). Use of high average dose statins for more than 1 year was associated with a lower risk of dementia than use of low average dose. However, there was no significant difference in dementia risks between lipophilic and hydrophilic statins. Fibrates or other lipid-lowering agents had no significant association with dementia risk. Conclusion: Our results suggest that long-term use of statin is associated with a reduced dementia risk. ? The Author(s) 2014. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84907215636&doi=10.1177%2f0891988714522702&partnerID=40&md5=8b8ad43def1c9e4f2e07066931577509 https://scholars.lib.ntu.edu.tw/handle/123456789/520496 |
ISSN: | 0891-9887 | DOI: | 10.1177/0891988714522702 | SDG/關鍵字: | antilipemic agent; fibric acid derivative; hydroxymethylglutaryl coenzyme A reductase inhibitor; adult; aged; Article; case control study; comorbidity; controlled study; dementia; drug exposure; drug use; dyslipidemia; female; hospital patient; human; long term care; major clinical study; male; outpatient; risk assessment; Taiwan; article; dementia; dose response; drug therapy; epidemiology; middle aged; public health; risk; time; very elderly; dementia; epidemiology; pharmacotherapy; Aged; Aged, 80 and over; Case-Control Studies; Dementia; Dose-Response Relationship, Drug; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; National Health Programs; Risk; Taiwan; Time Factors |
顯示於: | 流行病學與預防醫學研究所 |
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