https://scholars.lib.ntu.edu.tw/handle/123456789/520496
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen P.-Y. | en_US |
dc.contributor.author | Liu S.-K. | en_US |
dc.contributor.author | Chen C.-L. | en_US |
dc.contributor.author | CHI-SHIN WU | en_US |
dc.date.accessioned | 2020-11-04T09:17:14Z | - |
dc.date.available | 2020-11-04T09:17:14Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0891-9887 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84907215636&doi=10.1177%2f0891988714522702&partnerID=40&md5=8b8ad43def1c9e4f2e07066931577509 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/520496 | - |
dc.description.abstract | Background: The effect of statin use on dementia risk remains unclear. This study aims to examine the association between long-term statin use and dementia risk. Methods: A nest case-control study within a nationwide representative populationbased cohort. Individuals aged 50 years and older participating in Taiwan's National Health Insurance program between 1998 and 2009 were enrolled. A total of 9257 patients with at least 3 outpatient or 1 inpatient claims records for dementia were identified. Comparison patients were selected at a 1:2 ratio from age- and sex-matched participants without dementia. The cumulative period and average daily dosages of statins, fibrates, and other lipid-lowering agents were measured. Results: The authors found a duration-response relationship, as dementia risk decreased by 9% per year of treatment of statins (adjusted odds ratio 0.91; 95% confidence interval, 0.85-0.97). Use of high average dose statins for more than 1 year was associated with a lower risk of dementia than use of low average dose. However, there was no significant difference in dementia risks between lipophilic and hydrophilic statins. Fibrates or other lipid-lowering agents had no significant association with dementia risk. Conclusion: Our results suggest that long-term use of statin is associated with a reduced dementia risk. ? The Author(s) 2014. | - |
dc.relation.ispartof | Journal of Geriatric Psychiatry and Neurology | - |
dc.subject | dementia; epidemiology; pharmacotherapy | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | antilipemic agent; fibric acid derivative; hydroxymethylglutaryl coenzyme A reductase inhibitor; adult; aged; Article; case control study; comorbidity; controlled study; dementia; drug exposure; drug use; dyslipidemia; female; hospital patient; human; long term care; major clinical study; male; outpatient; risk assessment; Taiwan; article; dementia; dose response; drug therapy; epidemiology; middle aged; public health; risk; time; very elderly; dementia; epidemiology; pharmacotherapy; Aged; Aged, 80 and over; Case-Control Studies; Dementia; Dose-Response Relationship, Drug; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; National Health Programs; Risk; Taiwan; Time Factors | - |
dc.title | Long-term statin use and dementia risk in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1177/0891988714522702 | - |
dc.identifier.pmid | 24578458 | - |
dc.identifier.scopus | 2-s2.0-84907215636 | - |
dc.relation.pages | 165-171 | - |
dc.relation.journalvolume | 27 | - |
dc.relation.journalissue | 3 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.orcid | 0000-0003-2762-7295 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 流行病學與預防醫學研究所 |
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