https://scholars.lib.ntu.edu.tw/handle/123456789/520930
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JYH-MING LIOU | en_US |
dc.contributor.author | CHIEH-CHANG CHEN | en_US |
dc.contributor.author | Chang, C.-M. | en_US |
dc.contributor.author | YU-JEN FANG | en_US |
dc.contributor.author | Bair, M.-J. | en_US |
dc.contributor.author | Chen, P.-Y. | en_US |
dc.contributor.author | Chang, C.-Y. | en_US |
dc.contributor.author | Hsu, Y.-C. | en_US |
dc.contributor.author | MEI-JYH CHEN | en_US |
dc.contributor.author | CHIEN-CHUAN CHEN | en_US |
dc.contributor.author | Lee, J.-Y. | en_US |
dc.contributor.author | Yang, T.-H. | en_US |
dc.contributor.author | Luo, J.-C. | en_US |
dc.contributor.author | Chen, C.-Y. | en_US |
dc.contributor.author | WEN-FENG HSU | en_US |
dc.contributor.author | YEN-NIEN CHEN | en_US |
dc.contributor.author | Wu, J.-Y. | en_US |
dc.contributor.author | Lin, J.-T. | en_US |
dc.contributor.author | TZU-PIN LU | en_US |
dc.contributor.author | Chuang, E.Y. | en_US |
dc.contributor.author | El-Omar, E.M. | en_US |
dc.contributor.author | MING-SHIANG WU | en_US |
dc.contributor.author | Taiwan Gastrointestinal Disease | en_US |
dc.contributor.author | ERIC YAO-YU CHUANG | en_US |
dc.creator | Liou J.-M.;Chen C.-C.;Chang C.-M.;Fang Y.-J.;Bair M.-J.;Chen P.-Y.;Chang C.-Y.;Hsu Y.-C.;Chen M.-J.;Chen C.-C.;Lee J.-Y.;Yang T.-H.;Luo J.-C.;Chen C.-Y.;Hsu W.-F.;Chen Y.-N.;Wu J.-Y.;Lin J.-T.;Tzu-Pin Lu;Chuang E.Y.;El-Omar E.M.;Wu M.-S.;Taiwan Gastrointestinal Disease;Helicobacter Consortium | - |
dc.date.accessioned | 2020-11-17T02:45:19Z | - |
dc.date.available | 2020-11-17T02:45:19Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1473-3099 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072514361&doi=10.1016%2fS1473-3099%2819%2930272-5&partnerID=40&md5=1d3ad95d71d3db1a37e88fcef63d089b | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/520930 | - |
dc.description.abstract | Background: In first-line treatment of Helicobacter pylori, we have previously shown that the eradication frequency was 83·7% (95% CI 80·4–86·6) for triple therapy for 14 days (T14; lansoprazole 30 mg, amoxicillin 1 g, and clarithromycin 500 mg, all given twice daily), 85·9% (82·7–88·6) for concomitant therapy for 10 days (C10; lansoprazole 30 mg, amoxicillin 1 g, clarithromycin 500 mg, and metronidazole 500 mg, all given twice daily), and 90·4% (87·6–92·6) for bismuth quadruple therapy for 10 days (BQ10; bismuth tripotassium dicitrate 300 mg four times a day, lansoprazole 30 mg twice daily, tetracycline 500 mg four times a day, and metronidazole 500 mg three times a day). In this follow-up study, we assess short-term and long-term effects of these therapies on the gut microbiota, antibiotic resistance, and metabolic parameters. Methods: This was a multicentre, open-label, randomised trial done at nine medical centres in Taiwan. Adult patients (>20 years) with documented H pylori infection were randomly assigned (1:1:1, with block sizes of six) to receive T14, C10, or BQ10. We assessed long-term outcomes (reinfection frequency, changes in the gut microbiota, antibiotic resistance, and metabolic parameters) in patients with available data, excluding all protocol violators and those with unknown post-treatment H pylori status. Faecal samples were collected before treatment and 2 weeks, 2 months, and at least 1 year after eradication therapy. Amplification of the V3 and V4 hypervariable regions of the 16S rRNA was done followed by high-throughput sequencing. Susceptibility testing for faecal Escherichia coli and Klebsiella pneumoniae was done. This trial is complete and registered with ClinicalTrials.gov, NCT01906879. Findings: Between July 17, 2013, and April 20, 2016, 1620 participants were randomly assigned to the three treatment groups (540 [33%] per group). 1214 (75%) attended 1-year follow-up and are included in this analysis. Compared with baseline, alpha diversity was significantly reduced 2 weeks after T14 (p=0·0002), C10 (p<0·0001), and BQ10 (p<0·0001) treatment. Beta diversity was also significantly altered 2 weeks after T14 (p=0·0010), C10 (p=0·0001), and BQ10 (p=0·0001). Alpha diversity and beta diversity were restored at week 8 (p=0·14 and p=0·918, respectively) and 1 year (p=0·14 and p=0·918) after T14, but were not fully recovered at week 8 and after 1 year in patients treated with C10 (p=0·0001 and p=0·013 at week 8; p=0·019 and p=0·064 at 1 year) and BQ10 (p<0·0001 and p=0·0002; p=0·001 and p=0·029). A transient increase at week 2 after T14 and C10 of the resistance rates of E coli to ampicillin-sulbactam (12% [15/127] to 66% [38/58] for T14, 7% [10/135] to 64% [28/44] for C10), cefazolin (13% [16/127] to 43% [25/58] for T14, 10% [13/135] to 41% [18/44] for C10), cefmetazole (8% [10/127] to 26% [15/58] for T14, 4% [5/135] to 18% [8/44] for C10), levofloxacin (8% [10/127] to 35% [20/58] for T14, 7% [10/135] to 32% [14/44] for C10), gentamicin (13% [19/146] to 47% [27/58] for T14, 15% [22/149] to 45% [20/44] for C10), and trimethoprim–sulfamethoxazole (33% [48/146] to 86% [50/58] for T14, 28% [42/148] to 86% [38/44] for C10; p<0·05 in paired samples in the above analyses) returned to basal state at week 8 and after 1 year. Although bodyweight and body-mass index slightly increased, there were significant improvements in metabolic parameters, with a decrease in insulin resistance, triglycerides, and LDL and an increase in HDL. Overall, there was no significant change in the prevalence of metabolic syndrome at week 8 and 1 year after T14, C10, and BQ10. Interpretation: Eradication of H pylori infection has minimal disruption of the microbiota, no effect on antibiotic resistance of E coli, and some positive effects on metabolic parameters. Collectively, these results lend support to the long-term safety of H pylori eradication therapy. Funding: National Taiwan University Hospital and Ministry of Science and Technology of Taiwan. ? 2019 Elsevier Ltd | en_US |
dc.publisher | Lancet Publishing Group | en_US |
dc.relation.ispartof | The Lancet Infectious Diseases | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amoxicillin; ampicillin; aztreonam; bismuth citrate; cefazolin; cefepime; cefmetazole; cefotaxime; ceftazidime; ceftriaxone; ciprofloxacin; clarithromycin; cotrimoxazole; ertapenem; gentamicin; high density lipoprotein; imipenem; lansoprazole; levofloxacin; low density lipoprotein; meropenem; metronidazole; piperacillin plus tazobactam; RNA 16S; sulfamethoxazole; sultamicillin; tetracycline; triacylglycerol; amoxicillin; antiinfective agent; bismuth citrate; clarithromycin; lansoprazole; metronidazole; organometallic compound; tetracycline; adult; antibiotic resistance; antibiotic sensitivity; Article; bacterial clearance; body mass; clinical outcome; controlled study; eradication therapy; Escherichia coli; feces analysis; female; follow up; gene amplification; Helicobacter infection; high throughput sequencing; human; insulin resistance; intestine flora; Klebsiella pneumoniae; major clinical study; male; metabolic parameters; middle aged; multicenter study; open study; priority journal; randomized controlled trial; systematic review; aged; antibiotic resistance; body mass; clinical trial; combination drug therapy; disease eradication; drug administration; drug effect; Helicobacter infection; Helicobacter pylori; intestine flora; metabolic syndrome X; microbiology; prevalence; procedures; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Body Mass Index; Clarithromycin; Disease Eradication; Drug Administration Schedule; Drug Resistance, Microbial; Drug Therapy, Combination; Escherichia coli; Female; Follow-Up Studies; Gastrointestinal Microbiome; Helicobacter Infections; Helicobacter pylori; Humans; Lansoprazole; Male; Metabolic Syndrome; Metronidazole; Middle Aged; Organometallic Compounds; Prevalence; Tetracycline | - |
dc.title | Long-term changes of gut microbiota, antibiotic resistance, and metabolic parameters after Helicobacter pylori eradication: a multicentre, open-label, randomised trial | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/S1473-3099(19)30272-5 | - |
dc.identifier.pmid | 31559966 | - |
dc.identifier.scopus | 2-s2.0-85072514361 | - |
dc.relation.pages | 1109-1120 | en_US |
dc.relation.journalvolume | 19 | en_US |
dc.relation.journalissue | 10 | en_US |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUHYL | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Medicine-NTUCC | - |
crisitem.author.dept | Institute of Health Data Analytics and Statistics | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Electrical Engineering | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.orcid | 0000-0002-7945-5408 | - |
crisitem.author.orcid | 0000-0003-2953-210X | - |
crisitem.author.orcid | 0000-0003-3284-004X | - |
crisitem.author.orcid | 0000-0001-7138-2614 | - |
crisitem.author.orcid | 0000-0003-3697-0386 | - |
crisitem.author.orcid | 0000-0002-1940-6428 | - |
crisitem.author.orcid | 0000-0003-2530-0096 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Life Science | - |
顯示於: | 流行病學與預防醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。