https://scholars.lib.ntu.edu.tw/handle/123456789/522345
Title: | Gender differences with dose-response relationship between serum selenium levels and metabolic syndrome-a case-control study | Authors: | CHIA-WEN LU HAO-HSIANG CHANG KUEN-CHEH YANG CHIEN-HSIEH CHIANG CHIEN-AN YAO KUO-CHIN HUANG |
Issue Date: | 2019 | Publisher: | MDPI AG | Journal Volume: | 11 | Journal Issue: | 2 | Source: | Nutrients | Abstract: | Few studies have investigated the association between selenium and metabolic syndrome. This study aimed to explore the associations between the serum selenium level and metabolic syndrome as well as examining each metabolic factor. In this case-control study, the participants were 1165 adults aged ?40 (65.8 ± 10.0) years. Serum selenium was measured by inductively coupled plasma-mass spectrometry. The associations between serum selenium and metabolic syndrome were examined by multivariate logistic regression analyses. The least square means were computed by general linear models to compare the serum selenium levels in relation to the number of metabolic factors. The mean serum selenium concentration was 96.34 ± 25.90 ?g/L, and it was positively correlated with waist circumference, systolic blood pressure, triglycerides, fasting glucose, and homeostatic model assessment insulin resistance (HOMA-IR) in women, but it was only correlated with fasting glucose and HOMA-IR in men. After adjustment, the odds ratios (ORs) of having metabolic syndrome increased with the selenium quartile groups (p for trend: <0.05), especially in women. The study demonstrated that the serum selenium levels were positively associated with metabolic syndrome following a non-linear dose-response trend. Selenium concentration was positively associated with insulin resistance in men and women, but it was associated with adiposity and lipid metabolism in women. The mechanism behind this warrants further confirmation. ? 2019 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066112074&doi=10.3390%2fnu11020477&partnerID=40&md5=e36a6857e6fd4c6edf2356450d0549f6 https://scholars.lib.ntu.edu.tw/handle/123456789/522345 |
ISSN: | 2072-6643 | DOI: | 10.3390/nu11020477 | SDG/Keyword: | glucose; hemoglobin A1c; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; selenium; selenoprotein; triacylglycerol; selenium; aged; Article; blood analysis; body mass; case control study; cholesterol blood level; female; food frequency questionnaire; glucose blood level; glucose metabolism; high density lipoprotein blood level; homeostasis model assessment; human; hyperlipidemia; hypertension; insulin resistance; interview; lipid metabolism; low density lipoprotein blood level; major clinical study; male; mass spectrometry; metabolic syndrome X; microparticle enzyme immunoassay; obesity; physical activity; questionnaire; risk factor; selenium blood level; sex difference; sphygmomanometry; systolic blood pressure; vitamin supplementation; waist circumference; blood; metabolic syndrome X; middle aged; sex factor; Aged; Case-Control Studies; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Obesity; Selenium; Sex Factors |
Appears in Collections: | 醫學系 |
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