Prevalence of genotype-specific human papillomavirus infection and cervical neoplasia in Taiwan: A community-based survey of 10,602 women
Journal
International Journal of Cancer
Journal Volume
128
Journal Issue
5
Pages
1192-1203
Date Issued
2011
Author(s)
Chen H.-C.
You S.-L.
Schiffman M.
Lin C.-Y.
Pan M.-H.
Chou Y.-C.
Liaw K.-L.
Hsing A.W.
Chen C.-J.
Abstract
Human papillomavirus (HPV) causes cervical neoplasia; but limited data are available from Asia. We conducted a large-scale community-based cohort study in Taiwan to estimate prevalence of genotype-specific HPV infection and cervical neoplasia. Following written informed consent, cervical cells for cytology and HPV testing were collected from 11,923 participants (aged 30-65 years old, mean 46.3) in 1991-1992. Genotyping was performed using MY11/GP6+ PCR-based HPV Blot (EasyChip) for 39 HPV types. The overall HPV prevalence was 16.2% for 10,602 eligible participants, and 13.8% for 10,190 cytologically normal participants. The most common carcinogenic types were HPV52 (2.5%), HPV16 (2.0%), HPV56 (1.8%), HPV18 (1.6%), HPV33 (1.2%), HPV58 (1.3%) and HPV39 (1.0%). Among the 56 prevalent invasive and in situ cases, HPV16 (48.2%) was most common, followed by HPV58 (25.0%), HPV52 (19.6%), HPV31 (8.9%), HPV33 (8.9%) and HPV18 (3.6%). HPV16 and HPV58 caused cytological HSIL+ at younger ages than HPV52. Approximately half of the cervical cancer cases and high-grade precursors in Taiwan could be prevented by prophylactic vaccines against HPV16 and HPV18 infection. Up to 40% more could be prevented by targeting HPV58, HPV52, HPV33 and HPV31, arguing for the introduction of vaccines including more types. ? 2010 UICC.
Subjects
cervical neoplasia; cohort; genotype; human papillomavirus; impact
SDGs
Other Subjects
adult; aged; carcinogen testing; cohort analysis; female; genotype; human; Human papillomavirus type 16; Human papillomavirus type 18; Human papillomavirus type 31; Human papillomavirus type 33; Human papillomavirus type 52; Human papillomavirus type 56; Human papillomavirus type 58; major clinical study; Papanicolaou test; papillomavirus infection; prevalence; priority journal; review; risk factor; Taiwan; uterine cervix carcinoma in situ; uterine cervix cytology; uterine cervix tumor; Wart virus; Adult; Aged; Alphapapillomavirus; Cohort Studies; Data Collection; Female; Genotype; Humans; Middle Aged; Prevalence; Taiwan; Uterine Cervical Neoplasms
Type
review