https://scholars.lib.ntu.edu.tw/handle/123456789/522642
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen H.-C. | en_US |
dc.contributor.author | You S.-L. | en_US |
dc.contributor.author | CHANG-YAO HSIEH | en_US |
dc.contributor.author | Schiffman M. | en_US |
dc.contributor.author | Lin C.-Y. | en_US |
dc.contributor.author | Pan M.-H. | en_US |
dc.contributor.author | Chou Y.-C. | en_US |
dc.contributor.author | Liaw K.-L. | en_US |
dc.contributor.author | Hsing A.W. | en_US |
dc.contributor.author | Chen C.-J. | en_US |
dc.creator | Chen H.-C. ;You S.-L. ;Chang-Yao Hsieh ;Schiffman M. ;Lin C.-Y. ;Pan M.-H. ;Chou Y.-C. ;Liaw K.-L. ;Hsing A.W. ;Chen C.-J. | - |
dc.date.accessioned | 2020-11-27T08:14:17Z | - |
dc.date.available | 2020-11-27T08:14:17Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78650744789&doi=10.1002%2fijc.25685&partnerID=40&md5=7cf0a9deec70650a999830fb764526cf | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/522642 | - |
dc.description.abstract | Human papillomavirus (HPV) causes cervical neoplasia; but limited data are available from Asia. We conducted a large-scale community-based cohort study in Taiwan to estimate prevalence of genotype-specific HPV infection and cervical neoplasia. Following written informed consent, cervical cells for cytology and HPV testing were collected from 11,923 participants (aged 30-65 years old, mean 46.3) in 1991-1992. Genotyping was performed using MY11/GP6+ PCR-based HPV Blot (EasyChip) for 39 HPV types. The overall HPV prevalence was 16.2% for 10,602 eligible participants, and 13.8% for 10,190 cytologically normal participants. The most common carcinogenic types were HPV52 (2.5%), HPV16 (2.0%), HPV56 (1.8%), HPV18 (1.6%), HPV33 (1.2%), HPV58 (1.3%) and HPV39 (1.0%). Among the 56 prevalent invasive and in situ cases, HPV16 (48.2%) was most common, followed by HPV58 (25.0%), HPV52 (19.6%), HPV31 (8.9%), HPV33 (8.9%) and HPV18 (3.6%). HPV16 and HPV58 caused cytological HSIL+ at younger ages than HPV52. Approximately half of the cervical cancer cases and high-grade precursors in Taiwan could be prevented by prophylactic vaccines against HPV16 and HPV18 infection. Up to 40% more could be prevented by targeting HPV58, HPV52, HPV33 and HPV31, arguing for the introduction of vaccines including more types. ? 2010 UICC. | - |
dc.relation.ispartof | International Journal of Cancer | - |
dc.subject | cervical neoplasia; cohort; genotype; human papillomavirus; impact | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adult; aged; carcinogen testing; cohort analysis; female; genotype; human; Human papillomavirus type 16; Human papillomavirus type 18; Human papillomavirus type 31; Human papillomavirus type 33; Human papillomavirus type 52; Human papillomavirus type 56; Human papillomavirus type 58; major clinical study; Papanicolaou test; papillomavirus infection; prevalence; priority journal; review; risk factor; Taiwan; uterine cervix carcinoma in situ; uterine cervix cytology; uterine cervix tumor; Wart virus; Adult; Aged; Alphapapillomavirus; Cohort Studies; Data Collection; Female; Genotype; Humans; Middle Aged; Prevalence; Taiwan; Uterine Cervical Neoplasms | - |
dc.title | Prevalence of genotype-specific human papillomavirus infection and cervical neoplasia in Taiwan: A community-based survey of 10,602 women | en_US |
dc.type | review | en |
dc.identifier.doi | 10.1002/ijc.25685 | - |
dc.identifier.pmid | 20853317 | - |
dc.identifier.scopus | 2-s2.0-78650744789 | - |
dc.relation.pages | 1192-1203 | - |
dc.relation.journalvolume | 128 | - |
dc.relation.journalissue | 5 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | review | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
Appears in Collections: | 醫學系 |
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