https://scholars.lib.ntu.edu.tw/handle/123456789/522642
Title: | Prevalence of genotype-specific human papillomavirus infection and cervical neoplasia in Taiwan: A community-based survey of 10,602 women | Authors: | Chen H.-C. You S.-L. CHANG-YAO HSIEH Schiffman M. Lin C.-Y. Pan M.-H. Chou Y.-C. Liaw K.-L. Hsing A.W. Chen C.-J. |
Keywords: | cervical neoplasia; cohort; genotype; human papillomavirus; impact | Issue Date: | 2011 | Journal Volume: | 128 | Journal Issue: | 5 | Start page/Pages: | 1192-1203 | Source: | International Journal of Cancer | Abstract: | Human papillomavirus (HPV) causes cervical neoplasia; but limited data are available from Asia. We conducted a large-scale community-based cohort study in Taiwan to estimate prevalence of genotype-specific HPV infection and cervical neoplasia. Following written informed consent, cervical cells for cytology and HPV testing were collected from 11,923 participants (aged 30-65 years old, mean 46.3) in 1991-1992. Genotyping was performed using MY11/GP6+ PCR-based HPV Blot (EasyChip) for 39 HPV types. The overall HPV prevalence was 16.2% for 10,602 eligible participants, and 13.8% for 10,190 cytologically normal participants. The most common carcinogenic types were HPV52 (2.5%), HPV16 (2.0%), HPV56 (1.8%), HPV18 (1.6%), HPV33 (1.2%), HPV58 (1.3%) and HPV39 (1.0%). Among the 56 prevalent invasive and in situ cases, HPV16 (48.2%) was most common, followed by HPV58 (25.0%), HPV52 (19.6%), HPV31 (8.9%), HPV33 (8.9%) and HPV18 (3.6%). HPV16 and HPV58 caused cytological HSIL+ at younger ages than HPV52. Approximately half of the cervical cancer cases and high-grade precursors in Taiwan could be prevented by prophylactic vaccines against HPV16 and HPV18 infection. Up to 40% more could be prevented by targeting HPV58, HPV52, HPV33 and HPV31, arguing for the introduction of vaccines including more types. ? 2010 UICC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78650744789&doi=10.1002%2fijc.25685&partnerID=40&md5=7cf0a9deec70650a999830fb764526cf https://scholars.lib.ntu.edu.tw/handle/123456789/522642 |
ISSN: | 0020-7136 | DOI: | 10.1002/ijc.25685 | SDG/Keyword: | adult; aged; carcinogen testing; cohort analysis; female; genotype; human; Human papillomavirus type 16; Human papillomavirus type 18; Human papillomavirus type 31; Human papillomavirus type 33; Human papillomavirus type 52; Human papillomavirus type 56; Human papillomavirus type 58; major clinical study; Papanicolaou test; papillomavirus infection; prevalence; priority journal; review; risk factor; Taiwan; uterine cervix carcinoma in situ; uterine cervix cytology; uterine cervix tumor; Wart virus; Adult; Aged; Alphapapillomavirus; Cohort Studies; Data Collection; Female; Genotype; Humans; Middle Aged; Prevalence; Taiwan; Uterine Cervical Neoplasms |
Appears in Collections: | 醫學系 |
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