https://scholars.lib.ntu.edu.tw/handle/123456789/522689
標題: | Hormonal and body-size factors in relation to breast cancer risk: A prospective study of 11,889 women in a low-incidence area | 作者: | Wu M.-H. Chou Y.-C. Yu J.-C. Yu C.-P. Wu C.-C. Chu C.-M. Yang T. Lai C.-H. CHANG-YAO HSIEH You S.-L. Chen C.-J. Sun C.-A. |
關鍵字: | Body Size; Breast Cancer; Hormonal Risk Factors; Prospective Study | 公開日期: | 2006 | 卷: | 16 | 期: | 3 | 起(迄)頁: | 223-229 | 來源出版物: | Annals of Epidemiology | 摘要: | PURPOSE: This prospective cohort study of 11,889 women was conducted to determine significant factors associated with the risk of breast cancer among Chinese women in Taiwan, a low-incidence area. METHODS: In-person interviews were completed for subjects to solicit information on hormonal factors. Measurements of height, weight, and waist-and- hip circumferences were performed by well-trained assistants using standardized techniques. Cox proportional hazards models were employed to estimate relative risks (RRs) and 95% confidence intervals (CIs). RESULTS: During an average follow-up time of 10.3 years (range: 1 to 11 years) with an accumulation of 134,063 person-years, 104 incident breast cancer cases were identified through data linkage with national cancer registry profile. There was a significant elevation in breast-cancer risk with increasing duration of the interval between age at menarche and age at first full-term pregnancy (FFTP). Additionally, central adiposity reflected by hip circumference was a significant predictor of breast cancer in this Chinese female population. CONCLUSIONS: The findings of this study indicated common mechanisms responsible for the higher incidence of breast cancer in Western populations may also explain the risk of breast cancer development in Taiwan, a low-incidence area. ? 2006 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-32944466281&doi=10.1016%2fj.annepidem.2005.02.015&partnerID=40&md5=6f3f23597a3bbcef1022d885c22534dd https://scholars.lib.ntu.edu.tw/handle/123456789/522689 |
ISSN: | 1047-2797 | DOI: | 10.1016/j.annepidem.2005.02.015 | SDG/關鍵字: | hormone; adult; age; anthropometry; article; body height; body size; body weight; breast cancer; cancer incidence; cancer registry; cancer risk; Chinese; confidence interval; female; human; interview; major clinical study; menarche; obesity; pregnancy; priority journal; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Body Mass Index; Body Size; Breast Neoplasms; China; Cohort Studies; Female; Hormones; Humans; Menarche; Middle Aged; Pregnancy; Proportional Hazards Models; Prospective Studies; Risk Factors; Taiwan |
顯示於: | 醫學系 |
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