Hormonal and body-size factors in relation to breast cancer risk: A prospective study of 11,889 women in a low-incidence area
Journal
Annals of Epidemiology
Journal Volume
16
Journal Issue
3
Pages
223-229
Date Issued
2006
Author(s)
Wu M.-H.
Chou Y.-C.
Yu J.-C.
Yu C.-P.
Wu C.-C.
Chu C.-M.
Yang T.
Lai C.-H.
You S.-L.
Chen C.-J.
Sun C.-A.
Abstract
PURPOSE: This prospective cohort study of 11,889 women was conducted to determine significant factors associated with the risk of breast cancer among Chinese women in Taiwan, a low-incidence area. METHODS: In-person interviews were completed for subjects to solicit information on hormonal factors. Measurements of height, weight, and waist-and- hip circumferences were performed by well-trained assistants using standardized techniques. Cox proportional hazards models were employed to estimate relative risks (RRs) and 95% confidence intervals (CIs). RESULTS: During an average follow-up time of 10.3 years (range: 1 to 11 years) with an accumulation of 134,063 person-years, 104 incident breast cancer cases were identified through data linkage with national cancer registry profile. There was a significant elevation in breast-cancer risk with increasing duration of the interval between age at menarche and age at first full-term pregnancy (FFTP). Additionally, central adiposity reflected by hip circumference was a significant predictor of breast cancer in this Chinese female population. CONCLUSIONS: The findings of this study indicated common mechanisms responsible for the higher incidence of breast cancer in Western populations may also explain the risk of breast cancer development in Taiwan, a low-incidence area. ? 2006 Elsevier Inc. All rights reserved.
Subjects
Body Size; Breast Cancer; Hormonal Risk Factors; Prospective Study
SDGs
Other Subjects
hormone; adult; age; anthropometry; article; body height; body size; body weight; breast cancer; cancer incidence; cancer registry; cancer risk; Chinese; confidence interval; female; human; interview; major clinical study; menarche; obesity; pregnancy; priority journal; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Body Mass Index; Body Size; Breast Neoplasms; China; Cohort Studies; Female; Hormones; Humans; Menarche; Middle Aged; Pregnancy; Proportional Hazards Models; Prospective Studies; Risk Factors; Taiwan
Type
journal article