https://scholars.lib.ntu.edu.tw/handle/123456789/523125
標題: | Nonalcoholic Fatty Liver Disease Is Associated With QT Prolongation in the General Population | 作者: | CHI-SHENG HUNG PING-HUEI TSENG CHIA-HUNG TU CHIEN-CHUAN CHEN WEI-CHIH LIAO YI-CHIA LEE HAN-MO CHIU HUNG-JU LIN YI-LWUN HO WEI-SHIUNG YANG MING-SHIANG WU MING-FONG CHEN |
公開日期: | 2015 | 卷: | 4 | 期: | 7 | 來源出版物: | Journal of the American Heart Association | 摘要: | BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is independently associated with QT prolongation among patients with diabetes. It has not yet been determined whether this association remains valid in the general population. We designed an observational study to explore this association.METHODS AND RESULTS: We conducted a cross-sectional analysis of 31 116 consecutive participants in our health management program. Heart rate-corrected QT (QTc) interval was derived from 12-lead electrocardiography and by Bazett's formula. NAFLD was diagnosed by abdominal ultrasonography and classified as none, mild, moderate, or severe, according to the ultrasonographic criteria. A multivariable linear regression model was fitted for the association between QTc interval and potential predictors (including demographic, anthropometric, biochemical factors, and comorbidities). Multivariable logistic regression analyses were fitted to assess the association between the severity of NAFLD and QTc prolongation, with the adjustment of significant predictors derived from multivariable linear regression. The mean QTc interval was 421.3 ms (SD 45.4 ms). In the multivariable linear regression analyses, mild, moderate, and severe NAFLD were associated with increases of 2.55, 6.59, and 12.13 ms, respectively, in QTc interval compared with no NAFLD (all P<0.001). In the multivariable logistic regression analyses, mild, moderate, and severe NAFLD were associated with an increased risk for QTc prolongation, with odds ratios of 1.11 (95% CI: 1.01 to 1.21, P<0.05), 1.61 (95% CI: 1.36 to 1.9, P<0.001), and 1.31 (95% CI: 1.16 to 2.24, P<0.01), respectively, in women, and 1.11 (95% CI: 1.01 to 1.21, P<0.05), 1.39 (95% CI: 1.22 to 1.59, P<0.001), and 1.87 (95% CI: 1.16 to 2.24, P<0.001), respectively, in men, after adjusting for predictors known to be associated with the QTc interval. The association remained significant among subgroups with or without diabetes.CONCLUSIONS: The severity of NAFLD was associated with a higher risk for QTc prolongation in the general population with and without diabetes. ? 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019456799&doi=10.1161%2fJAHA.115.001820&partnerID=40&md5=22a58c8bf5fb7b7347f9770c16f4541b https://scholars.lib.ntu.edu.tw/handle/123456789/523125 |
ISSN: | 2047-9980 | DOI: | 10.1161/JAHA.115.001820 | SDG/關鍵字: | action potential; adult; comorbidity; cross-sectional study; diagnostic imaging; echography; electrocardiography; female; heart muscle conduction system; heart rate; human; long QT syndrome; male; middle aged; multivariate analysis; Non-alcoholic Fatty Liver Disease; odds ratio; pathophysiology; prognosis; risk assessment; risk factor; severity of illness index; statistical model; Taiwan; time factor; Action Potentials; Adult; Comorbidity; Cross-Sectional Studies; Electrocardiography; Female; Heart Conduction System; Heart Rate; Humans; Linear Models; Logistic Models; Long QT Syndrome; Male; Middle Aged; Multivariate Analysis; Non-alcoholic Fatty Liver Disease; Odds Ratio; Prognosis; Risk Assessment; Risk Factors; Severity of Illness Index; Taiwan; Time Factors; Ultrasonography |
顯示於: | 醫學系 |
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