https://scholars.lib.ntu.edu.tw/handle/123456789/523277
標題: | High blood pressure in dementia: How low can we go? | 作者: | Turana Y. Tengkawan J. Chia Y.-C. Teo B.W. Shin J. Sogunuru G.P. Soenarta A.A. Minh H.V. Buranakitjaroen P. Chen C.-H. Nailes J. Hoshide S. Park S. Siddique S. Sison J. Sukonthasarn A. Tay J.C. TZUNG-DAU WANG Verma N. Zhang Y.-Q. Wang J.-G. Kario K. |
關鍵字: | Asia; cognitive dysfunction; dementia; hypertension; oldest old | 公開日期: | 2020 | 出版社: | Blackwell Publishing Inc. | 卷: | 22 | 期: | 3 | 起(迄)頁: | 415-422 | 來源出版物: | Journal of Clinical Hypertension | 摘要: | Hypertension is an important public health concern. The prevalence keeps increasing, and it is a risk factor for several adverse health outcomes including a decline in cognitive function. Recent data also show that the prevalence of hypertension and age-related dementia is rising in Asian countries, including in the oldest old group. This study aims to discuss possible treatments for high blood pressure in the elderly and propose an optimal target for BP relative to cognitive outcomes. This review discusses several studies on related blood pressure treatments that remain controversial and the consequences if the treatment target is too low or aggressive. Longitudinal, cross-sectional, and RCT studies were included in this review. An optimum systolic blood pressure of 120-130?mm?Hg is recommended, especially in nondiabetic hypertensive patients with significant risk factors. In the oldest old group of patients, hypertension might have a protective effect. The use of calcium channel blockers (CCB) and angiotensin receptor blocker (ARB) is independently associated with a decreased risk of dementia in older people. However, personalized care for patients with hypertension, especially for patients who are frail or very old, is encouraged. ? 2019 Wiley Periodicals, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076377016&doi=10.1111%2fjch.13752&partnerID=40&md5=ef5eb4b3287f1544b190a39ef54571cd https://scholars.lib.ntu.edu.tw/handle/123456789/523277 |
ISSN: | 1524-6175 | DOI: | 10.1111/jch.13752 | SDG/關鍵字: | angiotensin receptor antagonist; atenolol; calcium channel blocking agent; candesartan; diuretic agent; indapamide; perindopril; placebo; reserpine; antihypertensive agent; dipeptidyl carboxypeptidase inhibitor; blood pressure regulation; blood pressure variability; cardiovascular risk; cognition; community living; computer assisted tomography; dementia; diastolic blood pressure; disease association; elderly care; evidence based medicine; frail elderly; high risk population; human; hypertension; mild cognitive impairment; Mini Mental State Examination; nuclear magnetic resonance imaging; personalized medicine; priority journal; protection; Review; risk factor; risk reduction; systolic blood pressure; aged; Asia; blood pressure; combination drug therapy; cross-sectional study; dementia; drug effect; hypertension; very elderly; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Asia; Blood Pressure; Calcium Channel Blockers; Cross-Sectional Studies; Dementia; Drug Therapy, Combination; Humans; Hypertension |
顯示於: | 醫學系 |
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