https://scholars.lib.ntu.edu.tw/handle/123456789/523591
Title: | C-reactive protein and heart rate recovery in middle-aged men with severe obstructive sleep apnea | Authors: | MENG-YUEH CHIEN PEI-LIN LEE Tsai Y.-F. PAN-CHYR YANG Wu Y.-T. |
Issue Date: | 2012 | Journal Volume: | 16 | Journal Issue: | 3 | Start page/Pages: | 629-637 | Source: | Sleep and Breathing | Abstract: | Objective The study aimed to evaluate whether the inflammatory marker "high-sensitivity C-reactive protein (hsCRP)" level was associated with impaired heart rate recovery at 1 min after exercise termination (HRR-1) in middle-aged patients with severe obstructive sleep apnea (OSA). Methods Thirty middle-aged male patients (40-64 years old) with severe OSA (apnea-hypopnea index [AHI]? 30 h-1) and 30 subjects without OSA (AHI<5 h-1), matched with age and body mass index (BMI), were recruited. All subjects underwent an overnight polysomnography and completed a symptom-limited maximal exercise test. Cardiopulmonary parameters included peak oxygen consumption (VO 2peak) and heart rate response during and immediately after exercise. Fasting blood samples were drawn for hsCRP analysis. Result Patients with severe OSA had significantly higher hsCRP levels (0.18 vs. 0.07 mg/dl, P<0.01), lower reduced HRR-1, peak heart rate, and VO2peak values than those in the controls. The hsCRP levels significantly correlated with HRR-1 in the OSA group (r=-0.69, P<0.01) after adjustment for VO2peak (r=-0.66, P<0.01). Furthermore, stepwise multiple regression analysis showed that HRR-1 and AHI were significant predictors of hsCRP levels in all participants (adjusted R2=0.53, P<0.01). Conclusions Blunted HRR was shown in middle-aged men with severe OSA, and it was associated with high hsCRP levels significantly. ? Springer-Verlag 2011. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84867583107&doi=10.1007%2fs11325-011-0549-2&partnerID=40&md5=45c0356daf31cdec6cb0ee9004fb34a5 https://scholars.lib.ntu.edu.tw/handle/123456789/523591 |
ISSN: | 1520-9512 | DOI: | 10.1007/s11325-011-0549-2 | SDG/Keyword: | C reactive protein; adult; aged; apnea hypopnea index; article; blood sampling; body composition; body mass; cardiopulmonary exercise test; clinical article; controlled study; daytime somnolence; disease severity; Epworth sleepiness scale; heart rate recovery; human; male; measurement; middle aged; oxygen consumption; polysomnography; priority journal; sleep disordered breathing; vital sign; Adult; Arousal; C-Reactive Protein; Exercise Test; Heart Rate; Humans; Inflammation Mediators; Male; Middle Aged; Polysomnography; Reference Values; Sleep Apnea, Obstructive; Statistics as Topic; Sympathetic Nervous System |
Appears in Collections: | 醫學系 |
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