https://scholars.lib.ntu.edu.tw/handle/123456789/523643
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Yang S.-Y. | en_US |
dc.contributor.author | Yang T.-Y. | en_US |
dc.contributor.author | Chen K.-C. | en_US |
dc.contributor.author | Li Y.-J. | en_US |
dc.contributor.author | Hsu K.-H. | en_US |
dc.contributor.author | Tsai C.-R. | en_US |
dc.contributor.author | Chen C.-Y. | en_US |
dc.contributor.author | Hsu C.-P. | en_US |
dc.contributor.author | Hsia J.-Y. | en_US |
dc.contributor.author | Chuang C.-Y. | en_US |
dc.contributor.author | Tsai Y.-H. | en_US |
dc.contributor.author | KUAN-YU CHEN | en_US |
dc.contributor.author | Huang M.-S. | en_US |
dc.contributor.author | Su W.-C. | en_US |
dc.contributor.author | Chen Y.-M. | en_US |
dc.contributor.author | Hsiung C.A. | en_US |
dc.contributor.author | Shen C.-Y. | en_US |
dc.contributor.author | Chang G.-C. | en_US |
dc.contributor.author | PAN-CHYR YANG | en_US |
dc.contributor.author | Chen C.-J. | en_US |
dc.creator | Yang S.-Y. ;Pan-Chyr Yang Et Al. | - |
dc.date.accessioned | 2020-12-02T02:34:10Z | - |
dc.date.available | 2020-12-02T02:34:10Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1078-0432 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79954616695&doi=10.1158%2f1078-0432.CCR-10-2045&partnerID=40&md5=5de3302b901138a55e2838681db29c14 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/523643 | - |
dc.description.abstract | Purpose: To assess whether polymorphisms of genes related to estrogen biosynthesis and metabolism are associated with EGFR mutations. Experimental Design: We studied 617 patients with lung adenocarcinoma, including 302 neversmoking women. On the basis of multiple candidate genes approach, the effects of polymorphisms of CYP17, CYP19A1, ERα, and COMT in association with the occurrence of EGFR mutations were evaluated using logistic regression analysis. Results: In female never-smokers, significant associations with EGFR L858R mutation were found for the tetranucleotide (TTTA)n repeats in CYP19A1 (odds ratio, 2.6; 95%CI, 1.2-5.7 for 1 or 2 alleles with (TTTA) n repeats >7 compared with both alleles with (TTTA)n repeats ?7), and the rs2234693 in ERα (OR, 2.1; 95% CI, 1.1-4.0 for C/T and C/C genotypes compared with T/T genotype). The C/C genotype (vs. T/T genotype) of ERa was significantly associated with EGFR L858R mutation (OR, 3.0; 95% CI, 1.1-8.1), in-frame deletion (OR, 2.9; 95% CI, 1.1-7.6) and other mutations (OR, 4.3; 95% CI, 1.3-14.0). The genotype of COMT rs4680 was significantly associated with EGFR L858R mutation in female and male never-smokers showing OR's (95% CI) of 1.8 (1.0-3.2) and 3.6 (1.1-11.3), respectively, for genotypes G/A and G/G compared with genotype A/A. The number of risk alleles of CYP17, CYP19A1, ERα, and COMT was associated with an increasing OR of EGFR L858R mutation in female neversmokers (P = 0.0002 for trend). Conclusions: The L858R mutation of EGFR is associated with polymorphisms of genes related to estrogen biosynthesis and metabolism in never-smoking female lung adenocarcinoma patients. ? 2011 American Association for Cancer Research. | en_US |
dc.relation.ispartof | Clinical Cancer Research | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | aromatase; catechol methyltransferase; cytochrome P450 17; epidermal growth factor receptor; estrogen; estrogen receptor alpha; genomic DNA; adult; aged; amino acid substitution; article; cancer patient; cigarette smoking; controlled study; estrogen metabolism; estrogen synthesis; female; gene deletion; gene interaction; gene mutation; genetic association; genetic susceptibility; genotype; human; in frame deletion; lung adenocarcinoma; lung carcinogenesis; major clinical study; male; mutation rate; mutational analysis; nucleotide repeat; priority journal; single nucleotide polymorphism; tetranucleotide repeat; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Aromatase; Base Sequence; Biosynthetic Pathways; Catechol O-Methyltransferase; DNA Mutational Analysis; Estrogen Receptor alpha; Estrogens; Female; Genotype; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Polymorphism, Single Nucleotide; Receptor, Epidermal Growth Factor; Smoking; Steroid 17-alpha-Hydroxylase | - |
dc.title | EGFR L858R mutation and polymorphisms of genes related to estrogen biosynthesis and metabolism in never-smoking female lung adenocarcinoma patients | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1158/1078-0432.CCR-10-2045 | - |
dc.identifier.pmid | 21300759 | - |
dc.identifier.scopus | 2-s2.0-79954616695 | - |
dc.relation.pages | 2149-2158 | en_US |
dc.relation.journalvolume | 17 | en_US |
dc.relation.journalissue | 8 | en_US |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-5639-9773 | - |
crisitem.author.orcid | 0000-0001-6330-6048 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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