https://scholars.lib.ntu.edu.tw/handle/123456789/524184
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHIA-TI TSAI | en_US |
dc.contributor.author | HWANG, JUEY-JEN | en_US |
dc.contributor.author | FU-TIEN CHIANG | en_US |
dc.contributor.author | YI-CHIH WANG | en_US |
dc.contributor.author | Tseng C.-D. | en_US |
dc.contributor.author | Tseng Y.-Z. | en_US |
dc.contributor.author | JIUNN-LEE LIN | en_US |
dc.date.accessioned | 2020-12-02T09:15:26Z | - |
dc.date.available | 2020-12-02T09:15:26Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0008-6312 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-46849102209&doi=10.1159%2f000113419&partnerID=40&md5=045c43c719b26e1f95db863c3a365e96 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/524184 | - |
dc.description.abstract | Objectives: To test the association between renin-angiotensin system gene variants and atrial fibrillation (AF) using a regression approach. Methods: A total of 1,236 consecutive patients (227 with AF and 1,009 with normal sinus rhythm as controls) were recruited. Angiotensin-converting enzyme (ACE) gene I/D polymorphism; T174M, M235T, G-6A, A-20C, G-152A and G-217A polymorphisms of the angiotensinogen (AGT) gene, and A1166C polymorphism of the angiotensin II type I receptor (AT1R) gene were genotyped. We used a regression approach based on a generalized linear model to evaluate haplotype effects and to detect gene-gene interactions by incorporating interaction terms in the model. Results: In single-locus analyses, no locus was associated with AF. After adjustment for AF risk factors, we found significant differences in the global AGT gene haplotype profile (the global score statistic = 30.364, p = 0.001) and individual haplotype frequencies between AF patients and controls. Furthermore, significant 2-way gene-gene interactions between ACE I/D polymorphism and AGT gene haplotypes and between AT1R A1166C polymorphism and AGT gene haplotypes, and 3-way interaction between ACE I/D, AT1R A1166C and AGT gene haplotypes were detected. Conclusions: These results are compatible with the concept of multilocus and multigene effects in determining the risk of complex diseases such as AF, which would be missed with conventional single-locus approaches. Copyright ? 2008 S. Karger AG. | - |
dc.relation.ispartof | Cardiology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | aged; article; cardiac patient; female; gene frequency; gene interaction; gene locus; genetic polymorphism; genotype; haplotype; heart atrium fibrillation; human; major clinical study; male; priority journal; regression analysis; renin angiotensin aldosterone system; risk factor; scoring system; sinus rhythm; statistical model; Aged; Aged, 80 and over; Angiotensinogen; Atrial Fibrillation; Female; Haplotypes; Humans; Linear Models; Male; Middle Aged; Multifactorial Inheritance; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Receptor, Angiotensin, Type 1 | - |
dc.title | Renin-angiotensin system gene polymorphisms and atrial fibrillation: A regression approach for the detection of gene-gene interactions in a large hospitalized population | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1159/000113419 | - |
dc.identifier.pmid | 18239384 | - |
dc.identifier.scopus | 2-s2.0-46849102209 | - |
dc.relation.pages | 1-7 | - |
dc.relation.journalvolume | 111 | - |
dc.relation.journalissue | 1 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-4853-8665 | - |
crisitem.author.orcid | 0000-0001-6437-0455 | - |
crisitem.author.orcid | 0000-0003-4936-8968 | - |
crisitem.author.orcid | 0000-0003-2533-865X | - |
crisitem.author.orcid | 0000-0003-2148-3956 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。