Skip navigation
  • 中文
  • English

DSpace CRIS

  • DSpace logo
  • Home
  • Organizations
  • Researchers
  • Research Outputs
  • Explore by
    • Organizations
    • Researchers
    • Research Outputs
  • Academic & Publications
  • Sign in
  • 中文
  • English
  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/524388
DC FieldValueLanguage
dc.contributor.authorWang C.-Y.en_US
dc.contributor.authorLin Z.-F.en_US
dc.contributor.authorCHII-MING LEEen_US
dc.contributor.authorTsai Y.-W.en_US
dc.contributor.authorHuang T.-Y.en_US
dc.contributor.authorLI-JIUAN SHENen_US
dc.contributor.authorFEI-YUAN HSIAOen_US
dc.date.accessioned2020-12-04T04:18:59Z-
dc.date.available2020-12-04T04:18:59Z-
dc.date.issued2017-
dc.identifier.issn1053-8569-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85008497333&doi=10.1002%2fpds.4147&partnerID=40&md5=0db0bec48bb753186f3e126e7843df8d-
dc.identifier.urihttps://scholars.lib.ntu.edu.tw/handle/123456789/524388-
dc.description.abstractBackground: Existing studies suggested that concomitant use of calcium channel blockers (CCBs) may interfere with the antiplatelet effect of clopidogrel. The objective of this study was to examine the effect of concomitant use of CCBs and clopidogrel on risks of acute coronary syndrome (ACS) re-hospitalization in patients receiving percutaneous coronary intervention. Methods: Using the Taiwan National Health Insurance Research Database, we identified 51 925 patients who were admitted for newly diagnosed ACS, received percutaneous coronary intervention, and used clopidogrel within 1 year after discharge. We further stratified them into three groups based on their uses of guideline-recommended secondary prevention medications for ACS (fully, partially, and non-compliant groups) to assess the potential modification effect of guideline compliance. For each group, we conducted a 1:1 propensity score matching to minimize selection bias. Cox proportional hazard models were used to investigate the effect of concomitant use of CCBs (overall, subclasses, and individual CCBs) and clopidogrel on risks of ACS re-hospitalization. Results: Concomitant use of CCBs in patients discharged with clopidogrel was significantly associated with a lower risk of ACS re-hospitalization in the fully compliant group (HRfully compliant = 0.82 [95% confidence interval 0.75–0.89], p < 0.001) but was associated with increased risk of ACS re-hospitalization in the non-compliant group (HRnon-compliant = 1.22 [1.03–1.45], p = 0.0252). Conclusions: Different guideline compliance of secondary prevention medications could modify the potential drug–drug interaction between clopidogrel and CCBs. Concomitant use of CCBs and clopidogrel was significantly associated with increased risk of ACS re-hospitalization in ACS patients not compliant to guideline-recommended secondary prevention drugs. Copyright ? 2017 John Wiley & Sons, Ltd. Copyright ? 2017 John Wiley & Sons, Ltd.-
dc.publisherJohn Wiley and Sons Ltd-
dc.relation.ispartofPharmacoepidemiology and Drug Safety-
dc.subject.otheramlodipine; calcium channel blocking agent; clopidogrel; felodipine; antithrombocytic agent; calcium channel blocking agent; clopidogrel; ticlopidine; acute coronary syndrome; adult; Article; dual antiplatelet therapy; female; hospital discharge; hospital readmission; human; major clinical study; male; middle aged; percutaneous coronary intervention; practice guideline; priority journal; propensity score; secondary prevention; selection bias; Taiwan; acute coronary syndrome; aged; analogs and derivatives; combination drug therapy; drug interaction; factual database; hospital readmission; pathophysiology; procedures; proportional hazards model; protocol compliance; statistics and numerical data; very elderly; Acute Coronary Syndrome; Aged; Aged, 80 and over; Calcium Channel Blockers; Databases, Factual; Drug Interactions; Drug Therapy, Combination; Female; Guideline Adherence; Humans; Male; Middle Aged; Patient Readmission; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proportional Hazards Models; Secondary Prevention; Taiwan; Ticlopidine-
dc.subject.other[SDGs]SDG3-
dc.titleConcomitant use of calcium channel blockers with dual antiplatelet therapy and re-hospitalization for acute coronary syndromeen_US
dc.typejournal article-
dc.identifier.doi10.1002/pds.4147-
dc.identifier.pmid28067454-
dc.identifier.scopus2-s2.0-85008497333-
dc.relation.pages229-238-
dc.relation.journalvolume26-
dc.relation.journalissue3-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.openairetypejournal article-
item.fulltextno fulltext-
item.cerifentitytypePublications-
crisitem.author.deptInternal Medicine-NTUH-
crisitem.author.deptClinical Pharmacy-
crisitem.author.deptPharmacy-
crisitem.author.deptSchool of Pharmacy-
crisitem.author.deptClinical Pharmacy-
crisitem.author.deptPharmacy-
crisitem.author.deptSchool of Pharmacy-
crisitem.author.orcid0000-0002-1075-5787-
crisitem.author.orcid0000-0002-2854-3205-
crisitem.author.orcid0000-0003-1660-9120-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgCollege of Medicine-
crisitem.author.parentorgCollege of Medicine-
Appears in Collections:醫學系
Show simple item record

SCOPUSTM   
Citations

3
checked on Mar 13, 2023

WEB OF SCIENCETM
Citations

3
checked on Mar 12, 2023

Page view(s)

47
checked on Mar 23, 2023

Google ScholarTM

Check

Altmetric

Altmetric

Related Items in TAIR


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Sherpa Romeo網站查詢,以確認出版單位之版權政策。
    Please use Sherpa Romeo to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)
Build with DSpace-CRIS - Extension maintained and optimized by Logo 4SCIENCE Feedback