https://scholars.lib.ntu.edu.tw/handle/123456789/525008
標題: | Initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis: A ten-year retrospective study | 作者: | Tsai H.-Y. JYH-HONG LEE HSIN-HUI YU LI-CHIEH WANG YAO-HSU YANG BOR-LUEN CHIANG |
公開日期: | 2012 | 卷: | 111 | 期: | 10 | 起(迄)頁: | 542-549 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: The diagnosis of systemic onset juvenile idiopathic arthritis (SoJIA) on disease onset is challenging and made mainly by exclusion. This study aimed to investigate the initial clinical and laboratory features of children with SoJIA in Taiwan. Methods: Patients diagnosed with SoJIA at the National Taiwan University Hospital between 1997 and 2007 were evaluated and data were collected by retrospective chart review. Inferential statistics were used to compare features of patients with steroid use for <6 months or >6 months. Results: Twenty-eight (28) patients (13 boys and 15 girls) were included in this study. The mean age of onset was 8.7 years old. The most common presentations were fever (100%), arthritis (89.3%), and skin rash (67.9%). The patterns of arthritis in affected patients were 50% oligoarticular type and 39% polyarticular type. The most common joints involved were the knee (76% of patients with arthritis), ankle (56%), and elbow and proximal interphalangeal joints (28%). The most common pattern of fever during first week was intermittent (53%). Prolonged use of steroid was associated with leukocytosis (17.63±7.71 vs. 11.93±4.43×109 leukocytes/L, p<0.05) and higher aspartate aminotransferase (89.4 vs. 31.2U/L, p<0.05) on initial presentation. Conclusion: In SoJIA, extra-articular features such as fever, rash, and lymphadenopathy are most prominent. Leukocytosis and polyarticular pattern on presentation may indicate a refractory clinical course. ? 2012. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84867897397&doi=10.1016%2fj.jfma.2011.06.013&partnerID=40&md5=80e4867e79e41f9d1f5da1bb7322058b https://scholars.lib.ntu.edu.tw/handle/123456789/525008 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2011.06.013 | SDG/關鍵字: | aspartate aminotransferase; steroid; adolescent; ankle; ankle arthritis; arthritis; article; central retina vein occlusion; child; clinical article; clinical feature; disease association; disease course; drug use; elbow; female; fever; headache; hepatosplenomegaly; human; inflammation; interphalangeal joint; joint; juvenile rheumatoid arthritis; knee; knee arthritis; laboratory test; leukocyte; leukocytosis; lymphadenopathy; male; medical record review; preschool child; rash; retrospective study; school child; seizure; systemic onset juvenile idiopathic arthritis; Taiwan; treatment duration; uveitis; Adolescent; Ankle Joint; Arthritis, Juvenile Rheumatoid; Child; Child, Preschool; Elbow Joint; Exanthema; Female; Fever; Finger Joint; Headache; Hepatomegaly; Humans; Infant; Knee Joint; Leukocytosis; Lymph Nodes; Male; Retrospective Studies; Splenomegaly; Taiwan; Thrombocytosis |
顯示於: | 醫學系 |
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