https://scholars.lib.ntu.edu.tw/handle/123456789/525526
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin, Jainn-Jim | en_US |
dc.contributor.author | Lin, Kuang-Lin | en_US |
dc.contributor.author | Wang, Yu | en_US |
dc.contributor.author | Wang, Huei-Shyong | en_US |
dc.contributor.author | Hsia, Shao-Hsuan | en_US |
dc.contributor.author | LUAN-YIN CHANG | en_US |
dc.contributor.author | HUEI WANG | en_US |
dc.creator | Lin J.-J.;Lin K.-L.;Wang Y.;Wang H.-S.;Hsia S.-H.;Luan-Yin Chang;The Cheese Study Group | - |
dc.date.accessioned | 2020-12-15T07:41:57Z | - |
dc.date.available | 2020-12-15T07:41:57Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0387-7604 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959246787&doi=10.1016%2fj.braindev.2015.10.006&partnerID=40&md5=9d7de3ecf07789bb912c93a3fb6304ca | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/525526 | - |
dc.description.abstract | Background: Anti-glutamic acid decarboxylase antibodies are associated with encephalopathy, an autoimmune central nervous system inflammatory disease. The cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4)+49 A/G polymorphism has been shown to confer genetic susceptibility to positive anti-glutamic acid decarboxylase antibodies in patients with type 1 diabetes mellitus in Japan. We aimed to investigate the association of the CTLA-4+49 A/G (rs231775) polymorphism in Taiwanese children with anti-glutamic acid decarboxylase antibody-associated encephalopathy. Methods: This was a case-control study from July 2011 to June 2012 performed at Chang Gung Children's Hospital in Taiwan. Genotyping of the CTLA-4+49 A/G polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Results: Seventeen patients with anti-glutamic acid decarboxylase antibody-associated encephalopathy and 97 controls were enrolled. The genotype, allele and carrier frequencies of the CTLA-4+49 A/G polymorphism were equally distributed in the patients and controls, with no significant differences between the two groups. In addition, we found a positive trend between the level of anti-glutamic acid decarboxylase antibodies and the G allele of the CTLA-4+49 A/G polymorphism, although this trend was not statistically significant. Conclusions: Our results suggest that the CTLA-4+49 A/G (rs231775) polymorphism does not confer an increased susceptibility to anti-glutamic acid decarboxylase antibody-associated encephalopathy in Taiwanese children. ? 2015 The Japanese Society of Child Neurology. | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.ispartof | Brain and Development | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | cytotoxic T lymphocyte antigen 4; glutamate decarboxylase antibody; autoantibody; CTLA4 protein, human; cytotoxic T lymphocyte antigen 4; glutamate decarboxylase; adolescent; allergic encephalitis; antibody blood level; Article; case control study; child; clinical article; clinical feature; controlled study; epileptic state; female; fever; follow up; gene frequency; genetic association; genetic polymorphism; genetic susceptibility; genetic variability; genotype; glutamic acid decarboxylase antibody associated encephalopathy; human; male; preschool child; procedures; school child; Taiwanese; upper respiratory tract infection; vomiting; brain disease; genetic predisposition; genetics; immunology; restriction fragment length polymorphism; single nucleotide polymorphism; Taiwan; Adolescent; Autoantibodies; Brain Diseases; Child; Child, Preschool; CTLA-4 Antigen; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutamate Decarboxylase; Humans; Male; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Taiwan | - |
dc.title | CTLA-4+49 A/G polymorphism and antiglutamic acid decarboxylase antibody-associated encephalopathy in Taiwanese children | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.braindev.2015.10.006 | - |
dc.identifier.pmid | 26546236 | - |
dc.identifier.scopus | 2-s2.0-84959246787 | - |
dc.relation.pages | 419-426 | - |
dc.relation.journalvolume | 38 | - |
dc.relation.journalissue | 4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Communication Engineering | - |
crisitem.author.dept | Electrical Engineering | - |
crisitem.author.orcid | 0000-0003-2632-1956 | - |
crisitem.author.orcid | 0000-0002-9903-1979 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
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