|Title:||Immunogenicity and safety of a monovalent vaccine for the 2009 pandemic influenza virus A (H1N1) in children and adolescents||Authors:||CHUN-YI LU
|Issue Date:||2010||Journal Volume:||28||Journal Issue:||36||Start page/Pages:||5864-5870||Source:||Vaccine||Abstract:||
The 2009 pandemic influenza A (H1N1) has caused significant morbidity and mortality around the world. Safety and immunogenicity studies of 2009 pandemic influenza A (H1N1) virus in children and adolescents are limited. In this prospective, open-label study, 2 doses of a monovalent, unadjuvanted, inactivated, split-virus 2009 pandemic influenza virus A (H1N1) vaccine (AdimFlu-S) were administered to 183 healthy children and adolescents aged 1-17 years. Adverse reactions were assessed, and hemagglutination inhibition antibody titers were determined. Three weeks after the first dose, 36.2% of children aged 1-2 years, 52.5% of children aged 3-5 years, 56.7% of children aged 6-9 years, and 90.3% of adolescents aged 10-17 years generated protective antibodies. A second vaccination given 3 weeks later induced protective antibodies in 89.4% of all age groups. No severe adverse effects were found 6 weeks after vaccination. ? 2010 Elsevier Ltd.
|ISSN:||0264-410X||DOI:||10.1016/j.vaccine.2010.06.059||SDG/Keyword:||adimflu s; hemagglutination inhibiting antibody; influenza vaccine; unclassified drug; adolescent; antibody response; antibody titer; arm movement; article; child; child care; clinical trial; coughing; drug fever; drug safety; ecchymosis; female; headache; human; immunogenicity; infant; influenza A (H1N1); injection site pain; injection site rash; injection site reaction; injection site redness; injection site swelling; major clinical study; malaise; male; myalgia; nausea; nose congestion; pandemic influenza; preschool child; priority journal; rhinopharyngitis; school child; side effect; sore throat; treatment response; upper respiratory tract infection; vaccination; vomiting; Adolescent; Antibodies, Viral; Child; Child, Preschool; Female; Hemagglutination Inhibition Tests; Humans; Immunization Schedule; Infant; Influenza A Virus, H1N1 Subtype; Influenza Vaccines; Influenza, Human; Male; Prospective Studies; Vaccines, Inactivated
|Appears in Collections:||醫學系|
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