Pentoxifylline decreases post-operative intra-abdominal adhesion formation in an animal model
Journal
PeerJ
Journal Volume
2018
Journal Issue
8
Pages
e5434
Date Issued
2018
Author(s)
Yang Y.-L.
Lee M.G.
Liu C.-H.
Abstract
BACKGROUND: Intra-abdominal adhesions develop after nearly every abdominal surgery, commonly causing female infertility, chronic pelvic pain, and small bowel obstruction. Pentoxifylline (PTX) is a methylxanthine compound with immunomodulatory and antifibrotic properties. The aim of this study was to investigate whether PTX can reduce post-operative intra-abdominal adhesion formation via collagen deposition, tissue plasminogen activator (tPA) level, inflammation, angiogenesis, and fibrosis. METHODS: < 0.05 was considered statistically significant. RESULTS: cells at the site of adhesion. CONCLUSION: PTX may decrease intra-abdominal adhesion formation via increasing peritoneal fibrinolytic activity, suppressing angiogenesis, decreasing collagen synthesis, and reducing peritoneal fibrosis. Our findings suggest that PTX can be used to decrease post-operative intra-abdominal adhesion formation.
SDGs
Type
journal article