https://scholars.lib.ntu.edu.tw/handle/123456789/529264
Title: | Risk factors for infective endocarditis in children with congenital heart diseases - A nationwide population-based case control study | Authors: | Sun L.-C. Lai C.-C. Wang C.-Y. Wang Y.-H. Wang J.-Y. Hsu Y.-L. Hu Y.-L. EN-TING WU MING-TAI LIN Sy L.B. Chen L. |
Issue Date: | 2017 | Publisher: | Elsevier Ireland Ltd | Journal Volume: | 248 | Start page/Pages: | 126-130 | Source: | International Journal of Cardiology | Abstract: | Background Infective endocarditis (IE) is uncommon in childhood. Its associated epidemiological characteristics in patients with congenital heart disease (CHD) remain unclear. Methods The study population included children born in Taiwan during the years 1997 to 2005 who were diagnosed as having CHD before 3 years of age. All children were followed up until the end year of 2010, the diagnosis of infective endocarditis, or death. The demographic characteristics of patients with and without IE, the invasive procedures performed during 6 months before the index date, the prophylactic antibiotics related to dental procedures, and in-hospital mortality were collected. Results Information of 24,729 children with CHD were retrieved for our analysis and 237 patients with newly diagnosed IE were identified. The incidence rate of IE in all CHD lesions was 11.13 per 10,000 person-years. Taking ASD for reference, the following CHD lesions were at risk for IE: cyanotic CHD (adjusted OR, 9.58; 95% confidence interval, 5.38–17.05), endocardial cushion defect (ECD) (8.01; 2.73–23.50), Left-sided lesions (4.36; 1.90–10.01) and VSD (2.93; 1.64–5.23). Patients who underwent procedures have a higher risk of acquiring IE which include central venous catheter (CVC) insertion (3.17; 2.36–4.27), cardiac catheterization (3.74; 2.67–5.22), open-heart surgery (2.47; 1.61–3.77), valve surgery (3.20; 1.70–6.02), and shunt surgery (7.43; 2.36–23.41). However, dental procedures did not increase the risk of IE, irrespective of antibiotic usage. Conclusions The risk of IE varies markedly among CHD lesions in our study. Invasive heart procedures but not dental procedures, are more significantly associated with IE among children with CHD. ? 2017 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028341204&doi=10.1016%2fj.ijcard.2017.08.009&partnerID=40&md5=a95d3cd391f9ae1cb70782e767590fd7 https://scholars.lib.ntu.edu.tw/handle/123456789/529264 |
ISSN: | 0167-5273 | DOI: | 10.1016/j.ijcard.2017.08.009 | SDG/Keyword: | antibiotic prophylaxis; Article; bacterial endocarditis; cardiovascular risk; case control study; central venous catheterization; child; child death; cohort analysis; congenital heart disease; controlled study; cyanotic heart disease; dental procedure; disease association; endocardial cushion defect; female; follow up; heart atrium septum defect; heart catheterization; heart valve surgery; heart ventricle septum defect; hospital mortality; human; incidence; infant; infection risk; invasive procedure; major clinical study; male; newborn; open heart surgery; population based case control study; preschool child; priority journal; retrospective study; risk assessment; shunting; Taiwan; congenital heart malformation; endocarditis; epidemiology; health survey; mortality; procedures; risk factor; trends; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Endocarditis; Female; Follow-Up Studies; Heart Defects, Congenital; Hospital Mortality; Humans; Infant; Infant, Newborn; Male; Population Surveillance; Retrospective Studies; Risk Factors; Taiwan |
Appears in Collections: | 醫學系 |
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