Vascular endothelial growth factor in preterm infants with respiratory distress syndrome
Journal
Pediatric Pulmonology
Journal Volume
39
Journal Issue
5
Pages
461-465
Date Issued
2005
Author(s)
Abstract
Respiratory distress syndrome (RDS) secondary to surfactant deficiency is a common cause of morbidity and mortality in premature infants. Increasing evidence suggests that vascular endothelial growth factor (VEGF) may contribute to surfactant secretion and pulmonary maturation. However, differences in cord blood VEGF concentrations in infants with and without respiratory distress syndrome have not been reported. We hypothesized that premature infants with higher VEGF levels in cord blood had a lower risk of developing RDS. Cord blood samples were obtained from preterm infants born at 32 weeks of gestation or earlier. Infants were excluded if there was evidence of prenatal maternal infection or any infection within the first 3 days of life. Cord blood VEGF levels were measured using an enzyme-linked immunosorbent assay (ELISA). We found that neonates with clinically diagnosed RDS had a lower gestational age (GA), lower birth weight (BW), higher incidence of mechanical ventilation requirements, longer duration of mechanical ventilation, and lower Apgar scores at 1 and 5 min. Infants with RDS had significantly lower cord blood VEGF levels. GA, BW, premature rupture of membranes (PROM), and antenatal steroid treatment were not associated with changes in cord blood VEGF levels. The specificity of cord blood VEGF above 34 pg/ml for predicting the absence of RDS was 86%, the sensitivity was 53%, the positive predictive value was 84%, and the negative predictive value was 56%. Our data demonstrated that cord blood VEGF elevation was significantly correlated with an absence of RDS. ? 2005 Wiley-Liss, Inc.
SDGs
Other Subjects
lung surfactant; steroid; vasculotropin; Apgar score; article; artificial ventilation; blood sampling; controlled study; enzyme linked immunosorbent assay; female; fetus lung maturation; gestational age; high risk patient; human; incidence; infant; low birth weight; major clinical study; male; morbidity; mortality; neonatal respiratory distress syndrome; premature fetus membrane rupture; prematurity; prenatal period; priority journal; risk factor; sensitivity and specificity; umbilical cord blood; Apgar Score; Birth Weight; Female; Fetal Blood; Fetal Membranes, Premature Rupture; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Male; Predictive Value of Tests; Pregnancy; Pulmonary Surfactants; Respiration, Artificial; Respiratory Distress Syndrome, Newborn; Risk Factors; Sensitivity and Specificity; Steroids; Time Factors; Vascular Endothelial Growth Factor A
Type
journal article