https://scholars.lib.ntu.edu.tw/handle/123456789/532425
標題: | Viral hepatitis infection should be considered for evaluating uremic pruritus in continuous ambulatory peritoneal dialysis patients | 作者: | KUAN-YU HUNG Shyu R.-S. TUN-JUN TSAI Chen Wan Yu |
公開日期: | 1998 | 出版社: | S. Karger AG | 卷: | 16 | 期: | 3 | 起(迄)頁: | 147-153 | 來源出版物: | Blood Purification | 摘要: | Determining the possible association of viral hepatitis infection and degree of pruritus is the primary concern of this study. Ninety-six adequately dialyzed CAPD patients (47 male and 49 female) and 526 normal controls (266 male and 260 female) were enrolled. Blood hemoglobin, ferritin, electrolytes, calcium, phosphate, albumin, urea, creatinine, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase, and bilirubin were analyzed by routine methods. Serum HBsAg was examined, using a radioimmunoassay method and the anti-HCV, an enzyme immunoassay method. All cases were interviewed with a standardized questionnaire. The highest possible pruritus score (PS) was 22. The prevalences of HBsAg(+) and anti-HCV(+) were 14.6% and 17.7%, respectively. The mean PS in all 96 CAPD patients was 11.6 (range 7-22). The mean PS were 11.8 ± 0.6 and 12.5 ± 1.0 for patients infected with HBV and HCV, respectively. Both were significantly higher than that (10 ± 0.9) of patients without hepatitis infection. AST and ALT were significantly higher in patients infected with viral hepatitis than those without. The other biochemical parameters were not significant. Thirty-seven (38.5%) of our 96 patients had mild pruritus (PS ? 7) and 11 (15.9%) had severe pruritus (PS ? 15). Of the 83.9% (26/31) patients with viral hepatitis, the grades of skin itching were moderate to severe; whereas those of the patients without viral hepatitis, 53.6% (37/69) belonged to the group of moderate to severe pruritus (p = 0.003, χ2 test with Yates' correction). The authors recommended screening of viral hepatitis infection to be undertaken for uremic patients with unexplained skin itching. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031847974&doi=10.1159%2f000014328&partnerID=40&md5=3d5d8da4327c405a181844ac8239d7b2 https://scholars.lib.ntu.edu.tw/handle/123456789/532425 |
ISSN: | 0253-5068 | DOI: | 10.1159/000014328 | SDG/關鍵字: | alanine aminotransferase; albumin; alkaline phosphatase; aspartate aminotransferase; bilirubin; calcium; creatinine; electrolyte; ferritin; hemoglobin; hepatitis B surface antigen; hepatitis C antibody; phosphate; urea; adolescent; adult; aged; alanine aminotransferase blood level; albumin blood level; alkaline phosphatase blood level; article; aspartate aminotransferase blood level; bilirubin blood level; calcium blood level; continuous ambulatory peritoneal dialysis; controlled study; creatinine blood level; disease association; disease severity; electrolyte blood level; female; ferritin blood level; hemoglobin determination; human; interview; major clinical study; male; normal human; phosphate blood level; priority journal; pruritus; questionnaire; urea blood level; uremia; virus hepatitis |
顯示於: | 醫學系 |
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