https://scholars.lib.ntu.edu.tw/handle/123456789/535301
標題: | Seroprevalence of hepatitis A virus infection in persons with HIV infection in Taiwan: implications for hepatitis A vaccination | 作者: | HSIN-YUN SUN HSIANG-CHI KUNG Ho Y.-C. Chien Y.-F. Chen M.-Y. WANG-HUEI SHENG SZU-MIN HSIEH Wu C.-H. Liu W.-C. CHIEN-CHING HUNG SHAN-CHWEN CHANG |
公開日期: | 2009 | 卷: | 13 | 期: | 5 | 起(迄)頁: | e199-e205 | 來源出版物: | International Journal of Infectious Diseases | 摘要: | Objectives: To retrospectively determine the prevalence of anti-hepatitis A virus (HAV) antibody in HIV-positive persons with different routes of HIV exposure and to describe its characteristics in order to guide vaccination policy. Methods: The prevalence of anti-HAV antibody was compared between 1580 HIV-positive persons seeking medical attention and 2581 HIV-negative controls seeking health check-ups, who had undergone anti-HAV tests between 2004 and 2007. Comparisons were also made among groups of the HIV-positive patients who had acquired HIV via different routes of transmission. A multivariate logistic regression model was built to identify independent variables associated with anti-HAV seropositivity. Results: The overall prevalence of anti-HAV antibody was 60.9% in the HIV-positive and 48.0% in the controls (p < 0.001). The overall adjusted odds ratio (AOR) for positive anti-HAV antibody was 2.604 (95% confidence interval (CI) 2.106-3.219) in HIV-positive persons compared with HIV-negative persons. In addition, HIV-positive men who have sex with men (MSM), heterosexuals, and injecting drug users (IDU) all had significantly higher AOR for positive anti-HAV antibody than HIV-negative persons. In HIV-positive persons, older age (AOR 1.284, 95% CI 1.246-1.322) and IDU (AOR 5.137, 95% CI 3.499-7.542) were independently associated with an increased prevalence of anti-HAV antibody. Nearly 90% of the IDU had become seropositive for HAV after age 36-40 years, compared with heterosexuals and MSM after age 46-50 years, and controls after age 51-55 years. Conclusion: Our findings suggest that age groups to be targeted for HAV vaccination vary with the different routes of HIV exposure. ? 2009 International Society for Infectious Diseases. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-68949173501&doi=10.1016%2fj.ijid.2008.12.009&partnerID=40&md5=6636183f290a87210e1a9852e73aa0ea https://scholars.lib.ntu.edu.tw/handle/123456789/535301 |
ISSN: | 1201-9712 | DOI: | 10.1016/j.ijid.2008.12.009 | SDG/關鍵字: | hepatitis A antibody; adolescent; adult; article; comparative study; confidence interval; controlled study; drug use; female; groups by age; health care policy; hepatitis A; heterosexuality; human; Human immunodeficiency virus infection; major clinical study; male; male homosexual; medical examination; multivariate logistic regression analysis; retrospective study; risk factor; seroprevalence; Taiwan; vaccination; virus transmission; Hepatitis A; Hepatitis A Antibodies; Hepatitis A virus; HIV Infections; HIV-1; Humans; Male; Seroepidemiologic Studies |
顯示於: | 醫學系 |
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