https://scholars.lib.ntu.edu.tw/handle/123456789/535334
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lee Y.-C. | en_US |
dc.contributor.author | CHIEN-CHING HUNG | en_US |
dc.contributor.author | Tsai M.-S. | en_US |
dc.contributor.author | Zhang J.-Y. | en_US |
dc.contributor.author | Wu P.-Y. | en_US |
dc.contributor.author | Yang S.-P. | en_US |
dc.contributor.author | Luo Y.-Z. | en_US |
dc.contributor.author | Chang H.-Y. | en_US |
dc.contributor.author | Liu W.-C. | en_US |
dc.contributor.author | HSIN-YUN SUN | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.creator | Lee Y.-C.;Hung C.-C.;Tsai M.-S.;Zhang J.-Y.;Wu P.-Y.;Yang S.-P.;Luo Y.-Z.;Chang H.-Y.;Liu W.-C.;Hsin-Yun Sun;Chang S.-C. | - |
dc.date.accessioned | 2020-12-29T05:33:32Z | - |
dc.date.available | 2020-12-29T05:33:32Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84977469605&doi=10.1016%2fj.jmii.2016.04.011&partnerID=40&md5=c5f819f8cc2a8fba1814bba97e5500d0 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/535334 | - |
dc.description.abstract | Background/Purpose: To obtain current epidemiological data for better vaccination policies, this study aimed to assess the incidence and risk factors of herpes zoster in human immunodeficiency virus (HIV)-positive patients initiating combination antiretroviral therapy (cART) in Taiwan. Methods: Between June, 2012 and May, 2015, we prospectively identified zoster cases in HIV-positive patients initiating cART. Clinical information was collected on demographics, prior zoster, plasma HIV-1 RNA load (PVL), and CD4 count at baseline and during follow up. A case–control study by 1:2 matched pairs was used to identify the risk factors for zoster development. Results: During the 3-year study period, 826 patients with a mean age of 32.9 years were included, and 7.7% had prior zoster. The mean baseline CD4 count and PVL were 286 cells/μL and 4.90 log10 copies/mL, respectively. Fifty-four (6.5%) patients developed zoster after initiation of cART, with 43 episodes (79.6%) occurring within 1 year of cART initiation, which corresponded to an overall incidence rate of 3.61/100 person-years. The multivariate analysis revealed that prior zoster (adjusted odds ratio = 3.143; 95% confidence interval, 1.385–7.133) and baseline CD4 count < 200 cells/μL (adjusted odds ratio = 2.034; 95% confidence interval, 1.020–4.057) were independent risk factors for zoster in HIV-positive patients initiating cART. In case–control study, prior zoster and baseline PVL > 5 log10 copies/mL were risk factors for zoster development after cART initiation in multivariate analysis. Conclusions: Herpes zoster occurred in 6.5% of HIV-positive Taiwanese patients after initiation of cART, which was associated with prior zoster and baseline CD4 count < 200 cells/μL or baseline PVL > 5 log10 copies/mL. ? 2016 | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.ispartof | Journal of Microbiology, Immunology and Infection | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | atazanavir; integrase inhibitor; lamivudine plus zidovudine; nonnucleoside reverse transcriptase inhibitor; proteinase inhibitor; RNA directed DNA polymerase inhibitor; virus RNA; antiretrovirus agent; adult; antiretroviral therapy; Article; case control study; CD4 lymphocyte count; clinical assessment; cohort analysis; controlled study; drug substitution; drug withdrawal; epidemiological data; female; follow up; herpes zoster; human; Human immunodeficiency virus; Human immunodeficiency virus 1; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; incidence; infection risk; longitudinal study; major clinical study; male; medical information; prospective study; risk assessment; risk factor; Taiwan; treatment duration; vaccination; combination drug therapy; complication; herpes zoster; highly active antiretroviral therapy; Human immunodeficiency virus infection; incidence; pathogenicity; Varicella zoster virus; virus load; young adult; Adult; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Case-Control Studies; CD4 Lymphocyte Count; Cohort Studies; Drug Therapy, Combination; Female; Herpes Zoster; Herpesvirus 3, Human; HIV Infections; Humans; Incidence; Male; Risk Factors; Taiwan; Viral Load; Young Adult | - |
dc.title | Incidence and risk factors of herpes zoster in human immunodeficiency virus-positive patients initiating combination antiretroviral therapy in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jmii.2016.04.011 | - |
dc.identifier.pmid | 27329131 | - |
dc.relation.pages | 38-44 | - |
dc.relation.journalvolume | 51 | - |
dc.relation.journalissue | 1 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Tropical Medicine and Parasitology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.orcid | 0000-0001-7345-0836 | - |
crisitem.author.orcid | 0000-0003-0074-7721 | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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