https://scholars.lib.ntu.edu.tw/handle/123456789/535399
Title: | Echinocandins in invasive candidiasis | Authors: | Simon J. HSIN-YUN SUN Leong H.N. Barez M.Y.C. Huang P.-Y. Talwar D. Wang J.-H. Mansor M. Wahjuprajitno B. Patel A. Wittayachanyapong S. Sany B.S.M. Lin S.-F. Dimopoulos G. |
Issue Date: | 2013 | Publisher: | Blackwell Publishing Ltd | Journal Volume: | 56 | Journal Issue: | 6 | Start page/Pages: | 601-609 | Source: | Mycoses | Abstract: | We summarise a recent meeting, sponsored by Pfizer Inc., where experts in Asia shared their clinical experience in managing IC. The echinocandins have demonstrated good activity against non-albicans infections and also azole-resistant strains, both preclinically and in recent clinical trials. As well as proving efficacious, echinocandins have a favourable safety profile and are well tolerated, including among inpatient subpopulations, such as transplant recipients and those with renal or hepatic dysfunction. In addition the echinocandins generally have minimal drug-drug interactions, unlike the oral azoles, which have multiple effects on cytochrome P450-mediated drug metabolism. Echinocandins are characterised by a good safety profile, few drug-drug interactions and good susceptibilities. With the increase in potentially azole-resistant non-albicans infections, echinocandins may become the first-line treatment of choice for many patients. ? 2013 Blackwell Verlag GmbH. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886288504&doi=10.1111%2fmyc.12085&partnerID=40&md5=aa0fde63a7db1947bd70d6540d2832c5 https://scholars.lib.ntu.edu.tw/handle/123456789/535399 |
ISSN: | 0933-7407 | DOI: | 10.1111/myc.12085 | SDG/Keyword: | amphotericin B; anidulafungin; caspofungin; cytochrome P450; fluconazole; host factor; micafungin; abdominal pain; antifungal activity; antifungal susceptibility; area under the curve; Candida albicans; candidemia; critically ill patient; diarrhea; disease predisposition; drug clearance; drug efficacy; drug protein binding; drug safety; fever; fungus growth; graft recipient; hematopoietic stem cell transplantation; human; iatrogenic disease; in vitro study; infection risk; invasive candidiasis; maximum plasma concentration; minimum inhibitory concentration; nausea; phlebitis; priority journal; review; time to maximum plasma concentration; vomiting; candidaemia; critically ill; Echinocandins; Antifungal Agents; Candidiasis, Invasive; Echinocandins; Humans; World Health |
Appears in Collections: | 醫學系 |
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