https://scholars.lib.ntu.edu.tw/handle/123456789/535568
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | HSIANG-CHI KUNG | en_US |
dc.contributor.author | KUO-CHIN HUANG | en_US |
dc.contributor.author | Kao T.-M. | en_US |
dc.contributor.author | Lee Y.-C. | en_US |
dc.contributor.author | Chang F.-Y. | en_US |
dc.contributor.author | Wang N.-C. | en_US |
dc.contributor.author | Liu Y.-C. | en_US |
dc.contributor.author | Lee W.-S. | en_US |
dc.contributor.author | Liu H.-J. | en_US |
dc.contributor.author | Chen C.-I. | en_US |
dc.contributor.author | Chen C.-H. | en_US |
dc.contributor.author | LI-MIN HUANG | en_US |
dc.contributor.author | SZU-MIN HSIEH | en_US |
dc.date.accessioned | 2020-12-29T06:37:49Z | - |
dc.date.available | 2020-12-29T06:37:49Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77957753780&doi=10.1016%2fj.vaccine.2010.08.073&partnerID=40&md5=d9d354cf82e0349ef15bfd0b96fc515f | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/535568 | - |
dc.description.abstract | We conducted a multi-center, randomized, laboratory-blinded clinical trial in 185 healthy adults (<60 years) and 107 elders (>60 years) to examine the immunogenicity and safety of different doses of an inactivated, monovalent, non-adjuvanted, split vaccine against the 2009 pandemic influenza A (H1N1) virus. The 186 adults were assigned to three treatment groups, i.e., one 15μg hemagglutination (HA) antigen dose, two 15μg or 30μg HA doses in 3 weeks apart, and the 107 elders were treated with two 15μg or 30μg doses in 3 weeks apart. Prior to the vaccination, 4.8% subjects had hemagglutination-inhibition (HAI) antibody titers of 1:40 or more. By day 21 post-vaccination of one dose of 15μg HA, the seroprotective rate was 95.1% and 75.5% in subjects <60 and >65 years of age, respectively; by day 21 post the second 15μg HA dose, the seroprotective rates were 93.2% and 73.1%, respectively. The seroprotective rates for recipients of 30μg HA antigen by day 21 were 95.2% for subjects <60 years and 81.1% for subjects >65 years of age, that was boosted to 98.3% and 80.4%, respectively with a second dose of 30μg HA antigen. No vaccine-related serious adverse events occurred. The data indicated a single 15μg HA dose of the vaccine induced a protective immune response in most adults, including the elders >60 years of age, and a booster dose at the third week did not render a higher level of antibody response. ? 2010 Elsevier Ltd. | en_US |
dc.relation.ispartof | Vaccine | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | influenza vaccine; adult; aged; antibody response; antibody titer; article; chemotherapy induced emesis; chest tightness; clinical trial; controlled clinical trial; controlled study; coughing; dizziness; drug fever; drug safety; ecchymosis; eye disease; face edema; female; headache; hemagglutination; hemagglutination inhibition; human; immune response; immunogenicity; influenza A (H1N1); influenza vaccination; Influenza virus A H1N1; limb movement; major clinical study; malaise; male; multicenter study; myalgia; nausea; nose congestion; pain; pandemic influenza; phase 2 clinical trial; priority journal; respiratory distress; respiratory tract infection; side effect; single blind procedure; sore throat; swelling; Adult; Aged; Aged, 80 and over; Antibodies, Viral; Antibody Formation; Epidemics; Female; Hemagglutination Inhibition Tests; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Influenza A Virus, H1N1 Subtype; Influenza Vaccines; Influenza, Human; Male; Middle Aged; Taiwan; Vaccination; Young Adult | - |
dc.title | A clinical study to assess the immunogenicity and safety of a monovalent 2009 influenza A (H1N1) vaccine in an area with low-level epidemics of pandemic influenza | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.vaccine.2010.08.073 | - |
dc.identifier.pmid | 20817013 | - |
dc.relation.pages | 7337-7343 | en_US |
dc.relation.journalvolume | 28 | en_US |
dc.relation.journalissue | 45 | en_US |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Family Medicine | - |
crisitem.author.dept | Family Medicine-NTUH | - |
crisitem.author.dept | Health Behaviors and Community Sciences | - |
crisitem.author.dept | Psychology | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | National Taiwan University Children's Hospital | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.orcid | 0000-0002-6029-5520 | - |
crisitem.author.orcid | 0000-0002-9291-260X | - |
crisitem.author.orcid | 0000-0002-1879-4086 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Science | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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