|Title:||Age Distribution for T Cell Reactivity to Vaccinia Virus in a Healthy Population||Authors:||Hsieh S.-M.
|Issue Date:||2004||Journal Volume:||38||Journal Issue:||1||Start page/Pages:||86-89||Source:||Clinical Infectious Diseases||Abstract:||
The potential for bioterrorism involving smallpox has led to a debate about the durability of protective immunity against smallpox from vaccination. By assessing the T cell reactivity to vaccinia virus in a healthy population, we show that subjects who were vaccinated within the past 3 decades and who have a visible vaccination scar had remarkable T cell reactivity. However, person who were vaccinated within the past 3 decades but who do not have a scar and those who were vaccinated >4 decades ago had responses as low as those in unvaccinated subjects. Thus, we estimate that the significant T cell memory response to vaccinia virus from successful vaccination may persist for only 20-30 years. Furthermore, we found the vaccinia-specific cellular immunity could be easily assessed by determination of the frequencies of vaccinia-specific CD69 expression on T cell subsets. These data may help in the development of public health strategies to counter bioterrorism threats associated with smallpox.
|ISSN:||1058-4838||DOI:||10.1086/380460||metadata.dc.subject.other:||vaccinia vaccine; adult; age distribution; aged; article; controlled study; health status; human; immunoreactivity; nonhuman; normal human; population research; priority journal; scar; T lymphocyte; time; vaccination; vaccinia; Vaccinia virus; Adolescent; Adult; Age Distribution; Aged; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Bioterrorism; Child; Child, Preschool; Humans; Immunity, Cellular; Immunologic Memory; Lymphocyte Activation; Middle Aged; Population; Smallpox Vaccine; T-Lymphocyte Subsets; T-Lymphocytes; Vaccinia virus
|Appears in Collections:||醫學系|
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