https://scholars.lib.ntu.edu.tw/handle/123456789/536075
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | KUAN-YIN LIN | en_US |
dc.contributor.author | Lauderdale T.-L. | en_US |
dc.contributor.author | JANN-TAY WANG | en_US |
dc.contributor.author | SHAN-CHWEN CHANG | en_US |
dc.date.accessioned | 2020-12-30T02:44:14Z | - |
dc.date.available | 2020-12-30T02:44:14Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84958037779&doi=10.1016%2fj.jmii.2014.01.005&partnerID=40&md5=d8a46e917d31a803cbf50cbf70ff7b0f | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/536075 | - |
dc.description.abstract | Background: The prevalence and clinical impact on mortality of carbapenem-resistant Pseudomonas aeruginosa (CRPA) is unclear in Taiwan. We aim to clarify these clinical issues by using data from the Taiwan Surveillance of Antimicrobial Resistance (TSAR) program. Methods: Patients from five hospitals with their P. aeruginosa isolates collected by TSAR II-VII (2000-2010) program were considered as the potential study population. All patients with CRPA were enrolled as case patients. Patients with carbapenem-susceptible P. aeruginosa were randomly selected in a 1:1 ratio to case patients as control patients. CRPA isolates were tested for the presence of carbapenemase-producing genes. The clinical data were collected to identify risk factors for CRPA carriage and mortality of P. aeruginosa infection. Results: The overall prevalence of CRPA was 10.2% (349/3408), which increased significantly by the TSAR period (= 0.007). Among the 164 enrolled patients, the risk factor for carrying CRPA was previous fluoroquinolone exposure (= 0.004). The risk factors for mortality among 80 patients with infection by P. aeruginosa included: intensive care unit (ICU) setting, receipt of antifungal therapy, and presence of invasive devices (= 0.001, 0.010, and 0.017; respectively). Carbapenem resistance did not play a role. Among the 82 CRPA isolates enrolled in this study, 15 isolates were found to carry carbapenemase-producing genes. Conclusion: In Taiwan, the prevalence of CRPA and carriage of carbapenemase-producing genes was high. However, carbapenem resistance did not play a role in the mortality of patients with P. aeruginosa infections. ? 2014. | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.ispartof | Journal of Microbiology, Immunology and Infection | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amikacin; carbapenem; colistin; imipenem; levofloxacin; piperacillin plus tazobactam; antiinfective agent; carbapenem derivative; aged; antibiotic sensitivity; antibiotic therapy; Article; bacterial colonization; bacterial phenomena and functions; bacterial prevalence; carbapenem resistant Pseudomonas aeruginosa; comorbidity; controlled study; female; human; immunosuppressive treatment; infection risk; major clinical study; male; mortality; multicenter study; nonhuman; outcome assessment; predictive value; prevalence; Pseudomonas aeruginosa; Pseudomonas infection; sex ratio; Taiwan; adult; antibiotic resistance; drug effects; heterozygote; hospital; isolation and purification; microbiology; middle aged; prevalence; Pseudomonas aeruginosa; Pseudomonas Infections; risk factor; survival analysis; treatment outcome; very elderly; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactam Resistance; Carbapenems; Carrier State; Female; Hospitals; Humans; Male; Middle Aged; Prevalence; Pseudomonas aeruginosa; Pseudomonas Infections; Risk Factors; Survival Analysis; Taiwan; Treatment Outcome | - |
dc.title | Carbapenem-resistant Pseudomonas aeruginosa in Taiwan: Prevalence, risk factors, and impact on outcome of infections | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jmii.2014.01.005 | - |
dc.identifier.pmid | 24662016 | - |
dc.relation.pages | 52-59 | - |
dc.relation.journalvolume | 49 | - |
dc.relation.journalissue | 1 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Center for Infection Control | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.orcid | 0000-0001-6877-5345 | - |
crisitem.author.orcid | 0000-0002-0924-3469 | - |
crisitem.author.orcid | 0000-0001-6505-4139 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Administrative Unit | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
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