|Title:||Electrophysiological mapping and histological examinations of the swine atrium with sustained (≥24 h) atrial fibrillation: A suitable animal model for studying human atrial fibrillation||Authors:||Lin J.-L.
|Keywords:||Animal model; Antiarrhythmic drugs; Atrial compartmentalization; Atrial fibrillation; Electrophysiological mapping||Issue Date:||2003||Journal Volume:||99||Journal Issue:||2||Start page/Pages:||78-84||Source:||Cardiology||Abstract:||
Objectives: Interventional elimination of chronic persistent atrial fibrillation (AFib) remains difficult. An animal model mimicking the clinical situation is important. Methods and Results: Twenty-five adult pigs were implanted with a high-speed atrial pacemaker. After continuous pacing at 600 bpm for 6 weeks, 20 (91%) of the 22 survivals developed sustained AFib lasting for at least 24 h. Epicardial dense mapping revealed multiple coexisting reentrant wavelets in the left and the right atrium (LA and RA, respectively; 10.6 ± 2.9 vs. 7.6 ± 2.4 wavelets/cm2/s; p < 0.002). The mean local A-A intervals were 87.2 ± 14.6 ms in the LA and 103.3 ± 19.0 ms in the RA (p < 0.0002). Acute termination of sustained AFib was successful in 3 of the 5 pigs by propafenone, but in none of the 6 by dl-sotalol. Epicardial cryothermal ablation failed to terminate any AFib by compartmentalization of the RA free wall alone (4 pigs) or together with the LA appendage (4 pigs). Electron microscopic examination demonstrated diffuse perinuclear myolysis, myofibrillar fragmentation and mitochondrial crystal disruption in the atrium. Conclusions: Pacing-induced sustained AFib (? 24 h) in adult pigs is a feasible and efficient animal model with electrophysiological and histological characteristics closely similar to those seen in humans. Copyright ? 2003 S. Karger AG, Basel.
|ISSN:||0008-6312||DOI:||10.1159/000069728||SDG/Keyword:||propafenone; sotalol; animal tissue; article; catheter ablation; controlled study; cytolysis; disorders of mitochondrial functions; drug effect; electron microscopy; epicardium mapping; heart atrium fibrillation; heart atrium pacemaker; heart atrium pacing; heart left atrium; heart muscle cell; heart right atrium; histopathology; muscle atrophy; nonhuman; priority journal; swine; treatment failure; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Body Surface Potential Mapping; Cardiac Pacing, Artificial; Cryosurgery; Disease Models, Animal; Echocardiography; Electrophysiologic Techniques, Cardiac; Heart Atria; Heart Ventricles; Microscopy, Electron; Models, Cardiovascular; Myocytes, Cardiac; Pacemaker, Artificial; Propafenone; Stroke Volume; Survival Analysis; Swine; Treatment Outcome
|Appears in Collections:||醫學系|
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