https://scholars.lib.ntu.edu.tw/handle/123456789/536737
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Huang, Por-Jau | en_US |
dc.contributor.author | KUO-LIONG CHIEN | en_US |
dc.contributor.author | MING-FONG CHEN | en_US |
dc.contributor.author | LING-PING LAI | en_US |
dc.contributor.author | FU-TIEN CHIANG | en_US |
dc.date.accessioned | 2020-12-31T02:57:37Z | - |
dc.date.available | 2020-12-31T02:57:37Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0008-6312 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034907453&doi=10.1159%2f000047361&partnerID=40&md5=e85aec06c634dbf4d37b997b46093f2d | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/536737 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/95170 | - |
dc.description.abstract | In this 12-week, double-blind, parallel-group, comparative trial, 57 adult patients with mild-to-moderate hypertension were randomly allocated to receive imidapril or captopril, initially at a dose of 5 mg once a day and 25 mg twice daily, respectively. After 4 weeks of therapy, the dose of each drug was increased twice if diastolic blood pressure (DBP) remained ? 90 mm Hg. Both treatments effectively lowered DBP in a comparable manner. Mean changes from baseline in DBP at 12 weeks were -9.9 mm Hg for imidapril and -8.8 mm Hg for captopril (p = 0.488). Responder rates in patients receiving active treatment for at least 6 weeks were 53.9% for imidapril and 48% for captopril (p = 0.676). Both treatments were well tolerated. Adverse drug reactions were observed in 20.7% (6/29) of the imidapril group and 46.4% (13/28) of the captopril group (p < 0.05). A cough was the most frequent side effect, reported in 13.8% of the imidapril group and 35.7% of the captopril group. The results indicate that imidapril is as effective as captopril in the treatment of hypertension. Imidapril produces less adverse effects compared with captopril. ? 2001 S. Karger AG, Basel. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Cardiology | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | captopril; imidapril; adult; article; clinical trial; controlled clinical trial; controlled study; coughing; diarrhea; double blind procedure; drug efficacy; drug safety; drug tolerability; dysgeusia; essential hypertension; female; good clinical practice; human; impotence; major clinical study; male; priority journal; proteinuria; pruritus; quality of life; randomized controlled trial; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Captopril; Cough; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypertension; Imidazoles; Imidazolidines; Male; Middle Aged; Taiwan; Treatment Outcome | - |
dc.title | Efficacy and safety of imidapril in patients with essential hypertension: A double-blind comparison with captopril | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1159/000047361 | - |
dc.identifier.pmid | 11474160 | - |
dc.identifier.scopus | 2-s2.0-0034907453 | - |
dc.relation.pages | 146 | en_US |
dc.relation.journalvolume | 95 | en_US |
dc.relation.journalissue | 3 | en_US |
dc.relation.pageend | 150 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | with fulltext | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-4979-8351 | - |
crisitem.author.orcid | 0000-0001-6633-7632 | - |
crisitem.author.orcid | 0000-0002-9651-7420 | - |
crisitem.author.orcid | 0000-0003-4936-8968 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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